In Nicolaou's total synthesis of taxol (Ref.: J. Am. Chem. Soc. 1995, 117, 653) the carbonyl group in A was converted into a nucleophilic vinyl Lithium species (shown below). Outline a mechanism for the reaction and also identify the name of the reaction. -отвS -OTBS ArSO,NHNH2 2 eq. Buli

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In Nicolaou's total synthesis of taxol (Ref.: J. Am. Chem. Soc. 1995, 117, 653) the carbonyl group in A
was converted into a nucleophilic vinyl Lithium species (shown below). Outline a mechanism for the
reaction and also identify the name of the reaction.
-отвS
-отвS
ArSO,NHNH2
2 eq. Buli
A
Transcribed Image Text:In Nicolaou's total synthesis of taxol (Ref.: J. Am. Chem. Soc. 1995, 117, 653) the carbonyl group in A was converted into a nucleophilic vinyl Lithium species (shown below). Outline a mechanism for the reaction and also identify the name of the reaction. -отвS -отвS ArSO,NHNH2 2 eq. Buli A
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