In Drosophila, three autosomal genes have the following map 5 m.u. 10 m.u. a b + When a+ b+ c+ abc females are crossed to a bclabc males, how many flies of the phenotype a+ b c+ is expected among 1000 progeny assuming interference of 60%? A) 1 B) 2 C) 5 D) 3 E) 10
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- 1. Please consider the following pedigree. I 1 2 II 1 a) Assume that colour is controlled by a single sex-influenced gene where orange is expressed preferentially in females. Individuals I-1 and I-2 are homozygous for orange and blue respectively. Which individual/s in generation II will be blue? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be orange?In Drosophila, three autosomal genes have the following map:20 m.u. 10 m.u.a b ca. Provide the data, in terms of the expected numberof flies in the following phenotypic classes, whena+ b+ c+/ a b c females are crossed to a b c / a b c males. Assume 1000 flies are counted and that nointerference exists in this region.a+ b+ c+a b ca+ b ca b+ c+a+ b+ ca b c+a+ b c+a b+ cb. If the cross was reversed, such that a+ b+ c+ / a b cmales are crossed to a b c / a b c females, howmany flies would you expect in the same phenotypic classes?1. Please consider the following pedigree. I 1 II 1 a) Assume that colour is controlled by a single sex-influenced gene where green is expressed preferentially in males. Individuals I-1 and I-2 are homozygous for red and green respectively. Which individual/s in generation II will be red? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be green?
- I. Male Drosophila from a true-breeding wild-typestock were irradiated with X-rays and then mated withfemales from a true-breeding stock carrying the following recessive mutations on the X chromosome:yellow body (y), crossveinless wings (cv), cut wings(ct), singed bristles (sn), and miniature wings (m).These markers are known to map in the order:y - cv - ct - sn - mMost of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and snphenotypes. When this exceptional ct sn female wasmated with a male from the true-breeding wild-typestock, twice as many females as males appearedamong the progeny.a. What is the nature of the X-ray-induced mutationpresent in the exceptional female?b. Draw the X chromosomes present in the exceptional ct sn female as they would appear duringpairing in meiosis.c. What phenotypic classes would you expect to seeamong the progeny produced by mating the exceptional ct sn female with a normal male from a truebreeding wild-type…8. While vermilion is X-linked and brightens the eye color, brown is an autosomal recessive mutation that darkens the eye. Flies carrying both mutations lose all pigmentation and are white-eyed. Predict the Fl and F2 results of the following crosses: a) vermilion females X brown males b) brown females X vermilion malesEC1. In drosophila the cw (curly wings) gene and eb (ebony body) genes are found on the same chromosome 20 map units apart. A cross was made between an ebony bodied parental strain and a curly winged parental strain and the F1’s were test crossed. a) What are the genotypes of the parental strains? b) What are the genotypes of the F1’s? c) What is the genotype of the tester strain? d) What progeny phenotypes and genotypes do you expect, and in what proportions? For phenotypes use the mutant phenotype for any that the flies have, and wild-type if they have none. EC2. Here is a tetrad produced by mating a H Y strain to an h y strain. a) What is the tetrad type? b) What has recombined with what? EC3. In corn, a dihybrid for the recessive genes a and b is test-crossed. The distribution of the phenotypes is as follows: A B 122A b 118a B 81a b 79 a) Do the genes appear to be sorting independently? Look at map units here. b) Test your hypothesis with a chi-squared test.
- The normal sequence of markers on a certain Drosophila chromosome is ABCDE*FGHIJK, where the asterisk represents the centromere. Some flies were isolated with a chromosome aberration that has the following structure: ABCDE*FIJK . This represents a O a) deletion of GH segment O b) inversion of GH segment O c) deletion O d) deletion of centromere6). To investigate the genetic control of locomotive behavior in the diploid nematode, Caenorhabditis elegans, eight "wiggly" mutants were isolated, which wiggle in an uncoordinated way rather than smoothly gliding. These eight mutants were crossed together in all possible pairwise combinations, yielding the results summarized in the table above (+ means that all the progeny were wild type, and m means that all the progeny showed the wiggly mutant phenotype). Organize the eight mutations into con lementation groups, each consisting of a group of mutations affecting the same gene. 1 2 3 4 5 6 7 8 1 E N+E 2 3+1 m + m 4 5 + m m E+ + + EE 6 ++E E+ +EE m m + + + + + + + + + m 7 8 ++4 ∞+E +E m m ++ EIn Drosophila melanogaster white (w) and miniature (m) wings are controlled by X-linked recessive genes with a recombination fruequency between them of approximately 38%. Show the sexes, phenotypes and proportions of offspring expected from the following mating:a. ++/wm female X wm maleb. +m/w+ female X w+ malec. w+/+m female X ++ maleIf we assume that white eyes and miniature wings are not x-linked but are linkedto the autosomal genes, what phenotypic frequencies would you expect from this cross: ++/wm female X ++/wm male?
- Red eyes (r), brown color (b), and curled wings (c) are 3 recessive mutations that occur in house flies. These genes have already been mapped: r-b = 12 mu b-c = 18 mu r-c = 30 mu A fly with red eyes, brown color, and curled wings is crossed with a fly homozygous for the wild-type traits. The F1 males are crossed with females with the three mutant traits and 2000 progeny are produced. Find the number of observed double crossovers if the interference is 0.38. O 43 O 62 O 27 O 162. Drosophila females heterozygous for three recessive x-linked markers y (yellow bodies), ct (cut wings), and m (miniature wings) were crossed to y ct m males and the following progeny were obtained. F1 Phenotype Yellow, cut, miniature Wildtype Yellow Cut, miniature miniature Number cut 60 63 20 13 Yellow, cut 15 Yellow, miniature 5 22 2 a) F1 Genotype b) Recombinant or Parental? c) SCO, DCO, or NONE? a) Fill in the table with the genotypes of each progeny type, use + to indicate wildtype/dominant traits, show separate homologues. b) In the table, identify whether each progeny type is Recombinant (R) or Parental (P). c) In the table, identify whether each progeny type results from a single crossover (SCO), a double crossover (DCO), or no crossing over (NONE). d) Diagram the parental cross, clearly indicating allelic contributions from each homologue of parental flies. Heterozygous wild-type Female Fly X Hemizygous mutant Male fly // // e) Draw the genetic map showing correct order and…In fruit flies, you are mapping three genes in a three point cross. The mutants are hairy body (h), sepia colored eyes (se) and female sterility (g). You cross a heterozygous parent with a homozygous recessive parent and obtain the following results: Type Number h se g. 5 + se + 450 + se g 27 ++g_ h se + + + + h + g. h + + TOTAL is the gene in the middle and the distance in map units between se and g is Oh; 16.4 se; 7.1 Oh; 7.1 70 82 7 327 32 1000 se; 16.4