In a patient diagnosed with a Squamous cell carcinoma that exhibits high Base Excision Repair activity, you can predict that the tumor will be very sensitive to PARP1 Inhibitors. Group of answer choices True False
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- Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.For many years, targeted therapies for cancer treatment continue to be developed, however more and more patients are developing resistance to targeted therapies. Discuss one mechanism of resistance to targeted therapies for cancer and provide an example of how might creatively combat it using clinical concepts.The best strategy for treating a specific type of human tumor can depend on identifying the type of cell that became cancerous to give rise to the tumor. For some tumors that have colonized a distant location (metastasized), identifying the parental cell type can be difficult. Because the type of IF protein expressed is cell-type-specific, using monoclonal antibodies that react with only one type of IF protein can help in this identification. What IF proteins would you produce monoclonal antibodies against to identify (a) a sarcoma of muscle cell origin, (b) an epithelial cell carcinoma, and (c) an astrocytoma (glial cell tumor)?
- Chemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expressionYou are evaluating a patient with Nonpolyposis colorectal cancer and his biopsy pathology report reveals a defect in some TSGs involved in DNA mismatch repair, which of these genes is least likely to be implicated in this patients cancer? Group of answer choices SMAD4 MSH2 MLH1 PMS1Cold allodynia is a common side effect of platinum-based chemotherapy drugs. Define this term.
- The growth fraction of the cancer types A 8, C, and D are 23%, 45%, 56%, and 78%, respectively. Which type of cancer is more suceptible to the chemotherapy?Describe the progression of cancer from an early benign lesion to a genetically heterogeneous malignant tumour and how this knowledge is used to design current and future antineoplastic treatments can you please give this in maximum detail as i am trying to understand this in extensive detailNeuropathy is often a side effect of anti-cancer drug treatments. Which of the following drugs induce neuropathy by disrupting microtubule formation thereby inhibiting axonal transport? Select ALL that apply Paclitaxel Oxaliplatin Vincristine Bortezomib Thalidomide Cisplatin
- Looking at this statement, develop an argument and critically evaluate/discuss it, then discuss difficulties with PARP inhibitor therapy and developments/progression in the future, the statement is "New synthetic lethal strategies targeting DNA damage response in solid tumours have been developed as a result of the success of PARP inhibitor therapy in ovarian cancer.Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.RG, a 6-year-old child, has been diagnosed with Acute Lymphoblastic Leukemia (ALL). The standard treatment is 6-mercaptopurine (Purinethol), an inexpensive drug that inhibits proliferation and is effective against rapidly proliferating cells like cancer cells. The compound is an antimetabolite that interferes with DNA synthesis. However, about 10% of patients experience life-threatening toxicities. 6-mercaptopurine is metabolized and detoxified by the enzyme thiopurine-S-methyltransferase (TPMT). The most common SNPS correlated with low enzymatic activity are TPMT*3A, *3B, *3C and *2. They cause enhanced degradation of the enzyme. Genotyping reveals that RG has the following genotype: TPMT*3A/*2. Questions: 1. A patient with low TPMT enzyme activity would: Accumulate 6-mercaptopurine and experience toxic side effects Metabolize 6-mercaptopurine quickly and experience no anti-cancer benefits 2. The gene encoding TPMT has been sequenced in RG: TPMT*3A/*2. The patient would be classified…
