Imidazole (C3H4N2, FM 68.08) is a weak base with pKb = 7.01. You wish to make 250.0 mL of a  0.300 M buffer at pH 7.50. You can use one of two methods.  a. First, starting with imidazole and imidazole hydrochloride, what mass of each would you need to  combine and dilute to 250.0 mL to create your buffer?    b. Now, starting instead with imidazole and 0.500 M HCl, what mass of imidazole should you use, and  approximately how many milliliters of HCl will you need to add (before diluting to a final volume of  250.0 mL with water)?  c. Of the two methods, which one is preferable and why?

Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter15: Acid–base Equilibria
Section: Chapter Questions
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Imidazole (C3H4N2, FM 68.08) is a weak base with pKb = 7.01. You wish to make 250.0 mL of a 
0.300 M buffer at pH 7.50. You can use one of two methods. 


a. First, starting with imidazole and imidazole hydrochloride, what mass of each would you need to 
combine and dilute to 250.0 mL to create your buffer? 
 
b. Now, starting instead with imidazole and 0.500 M HCl, what mass of imidazole should you use, and 
approximately how many milliliters of HCl will you need to add (before diluting to a final volume of 
250.0 mL with water)? 


c. Of the two methods, which one is preferable and why? 

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