HO CF3 ÕH но Travoprost (pressure inside the eye, including glaucoma) a) Redraw the structure and incorporate suitable modifications or functional group(s) to: i) increase the polarity of the molecule ii) increase the lipophilicity of the molecule

HO CF3 ÕH но Travoprost (pressure inside the eye, including glaucoma) a) Redraw the structure and incorporate suitable modifications or functional group(s) to: i) increase the polarity of the molecule ii) increase the lipophilicity of the molecule

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter21: Lipids

Section: Chapter Questions

Problem 21.47P

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Question

part (ii) please

Travoprost is a drug used to treat the build-up of pressure in the eye. It is
administered as eye drops.
HỌ
CF3
HỖ
ÕH
Travoprost (pressure inside the eye, including glaucoma)
a) Redraw the structure and incorporate suitable modifications or functional group(s)
to:
i) increase the polarity of the molecule
ii) increase the lipophilicity of the molecule
In each case, briefly explain what change(s) you have incorporated and the rationale
behind your structural modification.

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Travoprost is a drug used to treat the build-up of pressure in the eye. It is administered as eye drops. HO CF3 ÕH Travoprost (pressure inside the eye, including glaucoma) a) Redraw the structure and incorporate suitable modifications or functional group(s) to: i) increase the polarity of the molecule ii) increase the lipophilicity of the molecule In each case, briefly explain what change(s) you have incorporated and the rationale behind your structural modification. b) Redraw the structure and identify 5 sites that could be targeted by metabolic enzymes, such as cytochrome P450s or transferases. Show two examples of structures arising from potential metabolic activity, using an enzyme or enzymes of your choice.
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