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Explain the retrosynthetic analysis of the Witting reaction and provide starting material for the following product.
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- Provide reagents and conditions for the following synthetic transformation.The compound eutypine is an antibacterial agent isolated from the fungus Eutypa lata. This fungus results in a disease common to vineyards called eutyposis. Give a sequence of reactions that will take the following reactant and give eutypine when the other reactants used in the sequence are acetylene and acetone.Show how to bring about each step in this synthesis of the herbicide propranil.
- Provide all needed reagents and conditions for each step.A common illicit synthesis of methamphetamine involves an interesting variation of the Birch reduction. A solution of ephedrine in alcohol is added to liquid ammonia, followed by several pieces of lithium metal. The Birch reduction usually reduces the aromatic ring, but in this case it eliminates the hydroxy group of ephedrine to give methamphetamine. Propose a mechanism, similar to that for the Birch reduction, to explain this unusual course of the reaction.The following are intermediate products in the stepwise synthesis of compound 1 from benzene. Give the correct sequence of reactions with the appropriate reagents that will lead to the correct intermediate products and final product.