Drug Clearance For example, if the ClT of penicillin is 15mL/min in a patient and penicillin has a VD of 12 L, then from the clearance definition, 15 mL of the 12 L would be cleared of drug per minute. Formula: ClT = Elimination Rate (microgram/min)           Plasma concentration (microgram/mL

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Q: Calculate the flow rate for a solution of 18 mg in 300 mL with a maintenance dose of 5 mcg/min.

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