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Distant regulatory sites are called:
a. Enhancers
b. Operators
c. Both a and b
d. None of the above
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- Positive regulators are called: A. Repressors B. Activators C. Enhancers D. None of the aboveIn a suppressor interaction, produce(s) a protein complex that is O a. 1 mutation, active b. 1 mutation, inactive С. 2 mutations, active d. 2 mutations, inactiveAnswers the following questions below: enhancers are: A.Proteins B.DNA regions C. Neither D. Both 2. mediators are: A. proteins B. DNA regions C. Neither D. Both
- Enhancers: a. are always located upstream of the TATA sequence b. are always within 200 bp of the TATA sequence c. are responsible for time and tissue specific transcription d. All the above are true.Regulatory transcription factors can be modulated by a. the binding of small effector molecules. b. protein-protein interactions. c. covalent modifications. d. all of the above.Translational control of gene expression occurs within thea. nucleus.b. cytoplasm.c. nucleolus.d. mitochondria.
- Which of the following consequences of mutations would likely to be associated with an increased cancer risk? (select all that apply)? A. Truncation of the EGF receptor B. Constitutive activation of K-Ras C. Amplification of myc D. Truncation of H-Ras due to a premature stop codon E. Amplification of ErbB2Which of the following is true of CpG islands? a. They are methylated near promoters of actively transcribed genes. b. They are unmethylated near promoters of actively transcribed genes. c. Acetylation of CpG islands leads to repression of transcription. d. CpG islands code for RNA molecules that activate transcription.Define the following terms:a. tumor promoterb. guanine nucleotide exchange factorc. DAGd. steady statee. IP3
- Is each of the following statements true or false? A. An enhancer is a type of regulatory element. B. A core promoter is a type of regulatory element. C. Regulatory transcription factors bind to regulatory elements. D. An enhancer may cause the down regulation of transcription.Binding of______ to_______ in DNA can increase the rate of transcription of specific genes. a. activators; repressors b. activators; enhancers c. repressors; operators d.repressors; enhancerEnzymes that have binding sites for modulators are specifically called a. zymogens b. quaternary proteins c. induced enzymes d. allosteric enzymes