Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products, compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TsO 2) HO Bn Decytonpolide A H Decytospolide R- COCH
Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products, compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TsO 2) HO Bn Decytonpolide A H Decytospolide R- COCH
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.50P: Following is the structure of miconazole, the active antifungal agent in a number of...
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