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Describe cell cycle and the role cyclin-cdk complexes play in the cell cycle.
-Write out what each phase is and how it is regulated.
-Describe the importance of each part and its checkpoints.
-Describe the three major cell cycle checkpoints
i) List each checkpoint
ii) Link that checkpoint to a type of DNA damage
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- Describe the three most important cell cycle checkpoints. Explain in a detailed manner and provide some sample scenarios.List and briefly describe three major cell cycle checkpoints. For each checkpoint, predict the consequences if the checkpoint fails to work properly.Which of the following is NOT a checkpoint that controls the progression of cell cycle? The metaphase checkpoint determines if all chromosomes are attached to the spindle apparatus Cytokinesis involves the formation of cleavage furrow to separate the cells The G2 checkpoint checks for DNA damage and determines if all of the DNA is replicated Cyclins and cyclin dependent kinases are protejns that are responsible for advancing a cell through the phases of the cell cycle
- "Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? ExplainCell cycle checkpoints are surveillance mechanisms that monitor the integrity and fidelity of the major events of the cell cycle. Which of the following are true about cell cycle checkpoints? Select all that apply The M phase checkpoint examines whether all sister chromatids are correctly attached to the spindle microtubules Progression through checkpoints is determined by the activation of cyclin dependent kinases bound to cyclins The G2 checkpoint is also called the restriction checkpoint O If a cell passes the G1 checkpoint, it irreversibly commits to complete the whole cell cycle and divideDescribe the purpose of cell cycle checkpoints.
- What is a role of cyclines in regulating the cell cycle? Describe the significance of checkpoints monitoring proteins check for aberrant cell cycle events.The process of cellular reproduction or divisions is a heavily regulated process for a number of different reasons. In the case of the eukaryotic cell there are a number of different checkpoints that a cell must pass before it can continue on. Please explain what those checkpoints are looking for and where those checkpoints are in the cell cycle. If a cell doesn’t pass any of these checkpoints what happens to those cells?1) List and briefly describe three major cell cycle checkpoints. For each checkpoint,predict the consequences if the checkpoint fails to work properly. 2) Explain why mitosis does not produce genetic variation and how meiosis leads to the production of tremendous genetic variation.
- "Agent V" is the name of an anticancer (chemotherapy) drug. This drug works against cancer cells by inhibiting the formation of microtubules in sensitive cells. Consider a cell that is sensitive to agent V (in other words, agent V is effective at stopping growth of this cell). Based on this information, agent V would cause the cell to be frozen at which of the major cell cycle checkpoints (G1, G2 or M checkpoint)? Explain your answer in 2- 4 sentences.The cell cycle contains a series of events that control the division of cells. It is controlled by which of the following: P. dephosphorylation of cyclin-dependent kinases (S) Q. binding of CDK inhibitor proteins (R) R. cyclin synthesis and degradation (P) S. phosphorylation of cyclin-dependent kinases (Q) R and S P, Q, R, and S Q and R P and QThe checkpoint permits cell entry into mitosis only if all DNA is replicated.* Start APC/C G2/M G1/S A hydrogen atom is sometimes referred to as a proton because O It is positively charged It is negatively charged It has just one proton It has just one electron How many chromosomes are in a human sex cell right after meiosis I? * O 46 O 23 92 4 Which protein family is responsible for facilitating the process of programmed cell death that is activated in cells with significant DNA damage? * O Separase OCaspase Cdk-cyclin OShugoshin O O O O O O O O