Consider a cohort study to compare the mortality rate of myocardial infarction (MI) in men with sedentary work (exposed group) to men with physically active work (unexposed). If in the exposed, there were 36,000 person (man) years of observation and 126 deaths whereas the unexposed had 24,000 man-years of observation and 44 deaths. Compute the following a) Mortality rate in each cohort? b) What is the relative risk of dying, comparing these 2 groups? c) What is the attributable risk of sedentary work?
Compound Probability
Compound probability can be defined as the probability of the two events which are independent. It can be defined as the multiplication of the probability of two events that are not dependent.
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Probability theory is a branch of mathematics that deals with the subject of probability. Although there are many different concepts of probability, probability theory expresses the definition mathematically through a series of axioms. Usually, these axioms express probability in terms of a probability space, which assigns a measure with values ranging from 0 to 1 to a set of outcomes known as the sample space. An event is a subset of these outcomes that is described.
Conditional Probability
By definition, the term probability is expressed as a part of mathematics where the chance of an event that may either occur or not is evaluated and expressed in numerical terms. The range of the value within which probability can be expressed is between 0 and 1. The higher the chance of an event occurring, the closer is its value to be 1. If the probability of an event is 1, it means that the event will happen under all considered circumstances. Similarly, if the probability is exactly 0, then no matter the situation, the event will never occur.
Question 7
Consider a cohort study to compare the mortality rate of myocardial infarction (MI) in men with sedentary work (exposed group) to men with physically active work (unexposed). If in the exposed, there were 36,000 person (man) years of observation and 126 deaths whereas the unexposed had 24,000 man-years of observation and 44 deaths.
Compute the following
- a) Mortality rate in each cohort?
- b) What is the relative risk of dying, comparing these 2 groups?
- c) What is the attributable risk of sedentary work?
- d) What is the attributable benefit of physical activity?
- e) If we assume that MI is associated with the mortality in this cohort (causality), what proportion of the disease in the higher group is potentially preventable?
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