Case Study A 45-year-old store manager complained of a burning, gnawing pain, moderately severe, almost always in the epigastric region. The pain is absent when he awakens, appears in midmorning, and is relieved by food but recurs two to three hours after a meal. The pain often awakens him at 1 or 2 a.m. An endoscopic examination and x-ray studies with barium showed normal stomach function but the presence of duodenal ulcers. Fasting serum gastrin levels were normal. H. pylori testing was negative. Treatments for this individual might include the following: Antacids: 15-30 mL of liquid or two to
GI Case Study
A 45-year-old store manager complained of a burning, gnawing pain, moderately severe, almost always in the epigastric region. The pain is absent when he awakens, appears in midmorning, and is relieved by food but recurs two to three hours after a meal. The pain often awakens him at 1 or 2 a.m. An endoscopic examination and x-ray studies with barium showed normal stomach function but the presence of duodenal ulcers. Fasting serum gastrin levels were normal. H. pylori testing was negative. Treatments for this individual might include the following:
Antacids: 15-30 mL of liquid or two to four tablets one to three hours after each meal and at bedtime for six weeks.
Histamine (H2) receptor antagonists: cimetidine (300 mg) or ranitidine (150 mg) with each meal and at bedtime for four to eight weeks.
Omeprazole (proton pump inhibitor): 20 mg two times a day.
Top of Form
- How does omeprazole act in treating this disorder?
- What is H. pylori?
- Most person who are H. pylori positive do not develop ulcers. What host (patient) factors would increase the risk that colonization with H. pylori would lead to the development of ulcer?
- If someone tests positive for H. Pylori, what is the typical treatment?
- How do NSAIDs cause ulcers?
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