The substrate has been represented bound to the enzyme pocket. 20 Zn Part A: Part B: Substrate Part C: lle Val A Increasing V Arg 1451 (1)=0 Carboxypeptidase A A. Competitive inhibitor B. Irreversible inhibitor C. Allosteric inhibition D. Uncompetitive inhibition E. Non-competitive inhibitor F. -1/KM Benzylsuccinic acid Propose the types of biochemical interactions by which benzylsuccinic acid interacts with the carboxypeptidase A active site. 1. Hydrogen bond II. Ionic bond III.Hydrophobic interactions (Choose from options G-L) Which of the shown Lineweaver-Burk plots would you expect observe when benzylsuccinic acid I used to inhibit Carboxypeptidase A enzymatic activity? (Choose from options N-R) Increasing [1] Benzylsuccinic acid (shown below) has been identified as an inhibitor of carboxypeptidase A. Based on your understanding of enzyme- inhibitor interactions, identify a likely mechanism of inhibition by benzylsuccinic acid. (Choose from options A-E) in-o CH3 1/S) O V.(min) 20 Zn + No inhibitor H₂N Products of peptidase reaction lle Val -1/KM Increasing (1) Arg IV max IASI m=0 Part C: 1/vo A Which of the shown Lineweaver-Burk plots would you expect enzymatic activity? (Choose from options N-R) B Increasing (1) 1/Vmax 1/[S] [1] = 0 A. Competitive inhibitor B. Irreversible inhibitor C. Allosteric inhibition D. Uncompetitive inhibitior E. Non-competitive inhibitor F. G. I only H. Il only 1. Ill only J. II and III only K. I and II only L. I, II and III M. N. Graph A O. Graph B P. Graph C Q. Graph D R. None of the given graphs 04/1 -1/KM Increasing [1], (1=0 1/[S] C ( N
The substrate has been represented bound to the enzyme pocket. 20 Zn Part A: Part B: Substrate Part C: lle Val A Increasing V Arg 1451 (1)=0 Carboxypeptidase A A. Competitive inhibitor B. Irreversible inhibitor C. Allosteric inhibition D. Uncompetitive inhibition E. Non-competitive inhibitor F. -1/KM Benzylsuccinic acid Propose the types of biochemical interactions by which benzylsuccinic acid interacts with the carboxypeptidase A active site. 1. Hydrogen bond II. Ionic bond III.Hydrophobic interactions (Choose from options G-L) Which of the shown Lineweaver-Burk plots would you expect observe when benzylsuccinic acid I used to inhibit Carboxypeptidase A enzymatic activity? (Choose from options N-R) Increasing [1] Benzylsuccinic acid (shown below) has been identified as an inhibitor of carboxypeptidase A. Based on your understanding of enzyme- inhibitor interactions, identify a likely mechanism of inhibition by benzylsuccinic acid. (Choose from options A-E) in-o CH3 1/S) O V.(min) 20 Zn + No inhibitor H₂N Products of peptidase reaction lle Val -1/KM Increasing (1) Arg IV max IASI m=0 Part C: 1/vo A Which of the shown Lineweaver-Burk plots would you expect enzymatic activity? (Choose from options N-R) B Increasing (1) 1/Vmax 1/[S] [1] = 0 A. Competitive inhibitor B. Irreversible inhibitor C. Allosteric inhibition D. Uncompetitive inhibitior E. Non-competitive inhibitor F. G. I only H. Il only 1. Ill only J. II and III only K. I and II only L. I, II and III M. N. Graph A O. Graph B P. Graph C Q. Graph D R. None of the given graphs 04/1 -1/KM Increasing [1], (1=0 1/[S] C ( N
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter26: Synthesis And Degradation Of Nucleotides
Section: Chapter Questions
Problem 22P
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