Based on this ASO test, which patient(s) definitely have CF? Patient 1,2,3 or 4? Based on this ASO test, which patient(s) do NOT have CF? Patient 1,2,3 or 4?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Based on this ASO test, which patient(s) definitely have CF? Patient 1,2,3 or 4?

Based on this ASO test, which patient(s) do NOT have CF? Patient 1,2,3 or 4?
 

There are over 600 different mutations in the CFTR gene that can lead to Cystic Fibrosis (autosomal recessive disorder)
Exons
14a
1 23 4 5 6a6b 7 8 9 10 1112 13 ¹4 14 15 1617a17b 1819202122 23 24
||| ||
||
Mutations
00
ASO A
WWO
ONO
ASO B
00●
70% of people with Cystic Fibrosis have a 3 base pair deletion in exon 10 (red
box.)
D
ASO A hybridizes to the wild type exon 10
ASO B hybridizes exon 10 containing the 3 base pair deletion
➖➖➖➖➖
100●
1 2
2 3 4
Transcribed Image Text:There are over 600 different mutations in the CFTR gene that can lead to Cystic Fibrosis (autosomal recessive disorder) Exons 14a 1 23 4 5 6a6b 7 8 9 10 1112 13 ¹4 14 15 1617a17b 1819202122 23 24 ||| || || Mutations 00 ASO A WWO ONO ASO B 00● 70% of people with Cystic Fibrosis have a 3 base pair deletion in exon 10 (red box.) D ASO A hybridizes to the wild type exon 10 ASO B hybridizes exon 10 containing the 3 base pair deletion ➖➖➖➖➖ 100● 1 2 2 3 4
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