b. How is it affected in this patient? 4. a. List three defects in the synthesis and/or secretion of thyroid hormone that could lead to hypothyroidism. b. Name two diseases and/or conditions that might cause one or more defects in the synthesis and/or secretion of thyroid hormone. 5. Would you expect to find a palpable goiter? Explain your answer. 6. Describe a suitable treatment for this individual
A 30-year-old male demonstrated a subtle onset of the following symptoms: dull facial expression; droopy eyelids; puffiness of the face and periorbital swelling; sparse, dry hair; dry, scaly skin; evidence of intellectual impairment; lethargy; a change of personality; bradycardia (60 b/min); a blood pressure of 90/70; anemia (hematocrit 27); enlarged heart (upon radiological exam); constipation, and hypothermia. Serum free T4 0.3 ng/dL (low).
Radioimmunoassay (RIA) of peripheral blood indicated elevated TSH levels. A TSH stimulation test, using recombinant human TSH, did not increase the output of thyroid hormones from the thyroid gland.
- What endocrine organ is involved here?
- a. Is this a primary or secondary disorder? What is a primary vs secondary disorder?
b. Why? What data is presented that supports your answer? Is a TSH and/or TRH determination necessary for your diagnosis?
3. a. Describe the normal complete feedback loop involved.
b. How is it affected in this patient?
4. a. List three defects in the synthesis and/or secretion of thyroid hormone that could lead to hypothyroidism.
b. Name two diseases and/or conditions that might cause one or more defects in the synthesis and/or secretion of thyroid hormone.
5. Would you expect to find a palpable goiter? Explain your answer.
6. Describe a suitable treatment for this individual
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