int IMLeagues | Provi...Time Remaining: 00:18:21A Hide Time Remaining AArsenic is a water soluble element that is a poison because it functions as an allosteric inhibitor of the citric acid cycle enzymes pyruvatedehydrogenase and succinate dehydrogenase. One of the consequences of arsenic poisoning is lactic acidosis from the buildup of lactate in thebody. Why does arsenic treatment result in a buildup of lactate?LegendPyruvateAcetylHydrogenCOA SH + NAD+Pyruvate dehydrogenaseCo,+NADH, H*AdenosineCarbonATRtriphosphateCoAОхygenGuanosineCGTP triphosphateSulfurAcetyl-CoACOA SHQCoenzyme QCoACoenzyme AHCO3 +CATPWaterNADH Nicotinamide adenine dinucleotideCitratePyruvate carboxylasePyruvate dehydrogenase EnzymeADP+PiCitrate synthaseAconitaseOxaloacetateWatercis-AconitateWaterNADH, H*AconitaseMalate dehydrogenaseNAD.D-IsocitrateNAD*MalateNADH, H*Isocitrate dehydrogenaseCO2Citric acid cycleFumaraseMacBook Pr V Show Time RemainingNAD*MalateCitric acid cycleNADH, H*Isocitrate dehydrogenaseCO2со,FumaraseWatera-ketoglutarateNAD*+ COA SHFumaratea-ketoglutarate dehydrogenaseNADH, H*+ CO,Succinyl-CoAQH2Succinyl-CoA synthetaseCoAGDP + PiSuccinic dehydrogenaseSuccinateCOA -SH + CGTPO A. When the citric acid cycle can't operate, cells are forced to rely on glycolysis alone for ATP production, which produces lactate as a fermentation by-product.O B. Arsenic reacts with pyruvate and converts it into lactate.O C. Inhibiting these enzymes in the citric acid cycle causes a feed-forward loop in which the electron transport chain reduces pyruvate to make lactateinstead of water.O D. Arsenic inhibits regeneration of NAD during fermentation, causing a lactate buildup.Reset Selection

For decades, arsenic toxicity to humans has been established, but human arsenic toxicology appears…

Arsenic is a water soluble element that is a poison because it functions as an allosteric inhibitor of the citric acid cycle enzymes pyruvate dehydrogenase and succinate dehydrogenase. One of the consequences of arsenic poisoning is lactic acidosis from the buildup of lactate in the body. Why does arsenic treatment result in a buildup of lactate?

Arsenic is a water soluble element that is a poison because it functions as an allosteric inhibitor of the citric acid cycle enzymes pyruvate dehydrogenase and succinate dehydrogenase. One of the consequences of arsenic poisoning is lactic acidosis from the buildup of lactate in the body. Why does arsenic treatment result in a buildup of lactate?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 8P

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