An action potential is considered an "all or nothing" event. What does this mean? Explain using the picture below to discuss what happens during each event. Use the letters in the diagram to match the events. +40 0- potential (mV)
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- Describe the normal anatomy (structure) and physiology (function) of a neuron, its supporting structures and the propagation of an action potential. 250 words maximum.a) Explain in detail what is occurring at stage A in the graph. (Be specific in terms of what's happening to the ion channels in your explanation if necessary!) b) What does this graph represent as a whole? Explain the main idea it portrays. +40| -70- A 1 2 4 Time/ms Potential Difference/mV B-60mV -90mV -70mk Refer to the figure of 3 action potentials. The spike height of this/these action potential(s) would depend on the concentration of extracellular sodium. A and B A only B only C only B and C
- Draw the current that you would expect to flow during a voltage clamp experiment on a typical neuron. Voltages and time course are shown. Briefly explain why the currents are inward or outward. Be sure to provide scale bars. You should definitely label the Y axis so that the peak current value is obvious. Draw the Na+ current you would expect if there were physiological ionic gradients. Draw the K+ current you would expect if there are physiological ionic gradients. Draw the K+ current you would expect if the bath solution and the intracellular solution are both 125 mM.[Na*] [K*] This diagram is a drawing of normal conditions that occur in a neuron's axon (not all details are included). This stage that a living neuron would be in, would show that O no positive ions are inside the cell current is traveling down the axon O the cell will be at rest once the Na ions enter the cell O the cell is at rest O Na ions are predominantly outside the cellWhat letter(s) represent the starting point of an action potential?
- The following concentrations of Na+ and K+ ions: [Na+]o = 120 mM, [Na+]i = 6 mM,[K+]o = 2 mM, and [K+]i = 150 mM. Assuming that the further at the peak of the action potential, PK: PNa is 1 : 12. Calculate (Vm) at the peak of the action potentialConformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)Membrane Potential (mV) +35 0 -50 -70 0 A B C | 2 Time (milliseconds) 3 E 4 Use the figure showing phases of the action potential to answer the following question. Most of the voltage-gated sodium channels become open at label ____, and become inactivated at label
- You are recording from a cell with a resting membrane potential of -65 mV. You inject 100 pA of current, resulting 58.7 mV. What is the value of tau? With this in mind, what is the capacitance of the cell? Please provide relevant equations to illustrate your thought process. When you terminate the current injection, how long do you expect for it to take for the cell to repolarize to -63 mV?What property is responsible for the initial ramp of the membrane potential at the onset of the current pulse?A: Membrane capacitanceB: Membrane resistance explain your choiceIn the figure to the left, name the 4 phases of the action potential (Note: you have to write in where phase 4 occurs). Describe what happens in each phase with a focus on Na+ and K+ flow through channels and the membrane potential. Discuss the importance of threshold. How does this relate to the concept of APs being all or none?