Although not present in animals, many plants and microorganisms can use a modified form of the citric acid cycle known as the glyoxylate cycle. This is beneficial in that: A. it does not release CO2 which is toxic to these organisms. B. it allows the organisms which possess it to convert acetyl CoA into glucose precursors. C. it provides a source of glyoxylate which is an essential molecule in biosynthetic pathways in these organisms.
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- Which of the following statements is true about the citric acid cycle a. The Citric Acid Cycle is an 8-step cycle that produces the most electron carrier molecules throughout the process of cellular respiration. b. In Citric Acid Cycle, both the acetyl group and coenzyme A of Acetyl CoA are combined to oxaloacetate. c. In Citric Acid Cycle, glucose is only partially broken down and there are still remnants of glucose after this process. d. The ATP produced during this process is via oxidative phosphorylationThe citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, answering with only one option is incorrect. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4Characterize, in terms of number of carbon atomspresent, each of the following citric acid cycle changesas (1) a C4 to C4 change, (2) a C4 to C6 change, (3) a C5to C4 change, or (4) a C6 to C5 change.a. Oxaloacetate to citrateb. a-Ketoglutarate to succinyl CoAc. Fumarate to malated. Succinyl CoA to succinate
- The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, please choose more than one. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4(b) Fluoroacetate, prepared commercially for rodent control, is also produced by a South African plant. After entering a cell, fluoroacetate is converted to fluoroacetyl-CoA in a reaction catalyzed by the en- zyme acetate thiokinase: F-CH2COO + CoA-SH + ATP F-CH2CO-SCOA + AMP + PP The toxic effect of fluoroacetate was studied in an experiment using intact isolated rat heart. After the heart was perfused with 0.22 mM fluoroacetate, the measured rate of glucose uptake and glycolysis decreased, and glucose 6-phosphate and fructose 6-phosphate accumulated. Examination of the citric acid cycle intermediates revealed that their concentrations were below normal, except for citrate, with a concentration 10-fold higher than normal. (b1) the other cycle intermediates to be depleted? Explain. Why does it block the citric acid cycle? Where did the block in the citric acid cycle occur? What caused citrate to accumulate and (b2) structure of the end product of fluoroacetate metabolism?…The citric acid cycle is a critical sequence of reactions for energy production, which take place in the matrix of the mitochondria. The reaction cycle requires materials from the cytosol to be converted into acetyl CoA, which represents the starting point of a new cycle. Which of the following statements about acetyl CoA is true? (a) Acetyl CoA is recycled at the end of every cycle. (b) Oxaloacetate is attached to acetyl CoA to feed the citric acid cycle. (c) Triacylglycerol molecules are transported into the mitochondrial matrix and cleaved by lipases to produce acetyl CoA. (d) Oxaloacetate is converted directly into acetyl CoA to feed the citric acid cycle
- The two main goals of the citric acid cycle are: (a) citrate synthesis and gluconeogenesis (b).degradation of acetyl-CoA to produce energy and supply precursors for anabolism (c).degradation of pyruvate to produce energy and supply precursors for anabolism (d).degradation of glucose to produce energy and supply precursors for anabolism (e).degradation of pyruvate to produce energy and synthesize oxaloacetate for gluconeogenesisThe citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options except citrate. Which carbon in citrate will contain C14? 4 1 3 2 Which carbon(s) in isocitrate will contain C14? 1 2 3 4 5 6 Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4(c) (1 ) Fluoroacetate, prepared commercially for rodent control, is also produced by a South Afri- can plant. After entering a cell, fluoroacetate is converted to fluoroacetyl-CoA in a reaction catalyzed by the enzyme acetate thiokinase: F-CH2COO¯ + COA-SH + ATP F-CH2CO-SCOA + AMP + PPj The toxic effect of fluoroacetate was studied in an experiment using intact isolated rat heart. After the heart was perfused with 0.22 mM fluoroacetate, the measured rate of glucose uptake and glycolysis decreased, and glucose 6-phosphate and fructose 6-phosphate accumulated. Examination of the cit- ric acid cycle intermediates revealed that their concentrations were below normal, except for citrate, with a concentration 10-fold higher than normal. Where did the block in the citric acid cycle occur? What caused citrate to accumulate and the other cycle intermediates to be depleted? Explain. Why does it block the citric acid cycle? Fluoroacetyl-CoA is enzymatically transformed in the citric acid cycle.…
- Take a look at the citric acid cycle. Look at the entry of acetyl CoA as the first step and oxaloacetate as the final. Determine each absorbed amino acid's probable point of entrance in the cycle and indicate the stoichiometric quantity of the citric acid cycle intermediate or starting material generated per oligopeptide molecule. If an amino acid has many entrance points into the cycle, you may choose any of them as long as stoichiometric connections are maintained.alpha-ketoglutarate dehydrogenase will do which of the following: Select one: a. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide b. Succinate is oxidized to become fumarate forming FADH2 c. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH d. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) e. Malate is oxidized to become oxaloacetate forming NADH f. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADH g. Citrate is rearranged to become Isocitrate h. Fumarate is combined with water to become Malate i. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADHConsider the following statements: (1) the products of the first two stages of cholesterol biosynthesis are, respectively, mevalonate (C6) and isopentyl pyrophosphate (2) Over 90 percent of the total dietary lipids are triaglycerols (3) The activation stages of fatty acid oxidation involves both CoA & ATP Choices: a. Only one of the statements is true b. All three statements are true c. Two of the three statements are true d. None of the statements are true