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Acyclovir can be used to treated virus-infected cells. Explain how?
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- We have many antimicrobial drugs to treat bacterial infections, but very few for viruses. Why is it so difficult to treat viral infections? Hint: What would the targets for the drugs be?What are anticoagulants?What are the practicalapplications of anticoagulants,like heparin, in Medicine?Why is it better for a drug to be microbicidal than microbistatic?
- Antiretroviral drugs target various aspects of HIV replication and infection. Which of the following enzymes are targets of antiretroviral drugs? Select ALL that applya).reverse transcriptaseb)integrasec).ligased).proteasee).DNA polymeraseWhich antiretroviral drug class does Zidovudine (AZT) belong to? a) Non-nucleoside reverse transcriptase inhibitors (NNRTIs) b) Nucleoside reverse transcriptase inhibitors (NRTIs) c) Protease inhibitors d) Integrase inhibitors(c) Molnupiravir has not been approved but has been authorized for emergency use by the FDA under an EUA to treat mild to moderate COVID-19 infection. Briefly explain this decision made by FDA based on the knowledge of clinical trials. (d) Both drugs are not allowed to be prescribed to person under 18 years old due to insufficient clinical data. Why is it necessary to separately conduct clinical trials for a younger age group?