23,25 A study published in the journal PLoS One(https://doi.org/10.1371/journal.pone.0217796 ) in 2019 presented results ofa GWAS searching for loci impacting the risk of prolonged QRS inHispanic/Latino people living in the U.S. QRS prolongation has been associatedheart failure and cardiovascular mortality. The Manhattan plot belowsummarizes the results. The significance threshold for this study is shown as ahorizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at eachassociated locus are shown at the top of the corresponding SNP tower. Howmany loci containing at least one gene affecting prolonged QRS risk wereidentified?-log10(p)C10-20SCN5A-SCN10A23CDKN1AHAND1678VTI1A20191011SYT1MYOCD:...12 13 14 15 16 17 18 19 20 2122 XY Two of the loci identified in the 2019 study were not identified in prior GWASstudies focused on this trait in people of European or African ancestry, andthose studies identified some loci not identified in this 2019 study ofHispanic/Latino people. Which of the following statements is the most likelyexplanation for these discrepancies?Some of the genes impacting prolonged QRS risk are different in people of differentancestry groupsPeople of Hispanic/Latino ancestry have a higher overall risk of prolonged QRSThe methodology employed in this study was flawedPeople of Hispanic/Latino ancestry have a lower overall risk of prolonged QRS

Answer :- Genome-Wide Association Studies (GWAS) play a crucial role in understanding the genetic…

A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796 ) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as a horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one gene affecting prolonged QRS risk were identified?

A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796 ) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as a horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one gene affecting prolonged QRS risk were identified?

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter10: Biotechnology

Section: Chapter Questions

Problem 13CTQ: Identify a possible advantage and a possible disadvantage of a genetic test that would identify...

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A study published in the journal PLoS One (https://doi.org/10.1371/journal.pone.0217796) in 2019 presented results of a GWAS searching for loci impacting the risk of prolonged QRS in Hispanic/Latino people living in the U.S. QRS prolongation has been associated heart failure and cardiovascular mortality. The Manhattan plot below summarizes the results. The significance threshold for this study is shown as a horizontal line at -log₁0(p-value) ~7.5. The names of candidate genes at each associated locus are shown at the top of the corresponding SNP tower. How many loci containing at least one gene affecting prolonged QRS risk were identified? (d)oT301- 10- 8 0 1 SCN5A-SCN10A HAND1 CDKN1A VTI1A 8 9 10 11 SYT1 MYOCD : 12 13 14 15 16 17 18 19 20 2122 X Y
A DVT (deep vein thrombosis) clinic had 320 persons appearing for lower extremities Doppler ultrasound study. If 48 out of 80 subjects with DVT tested positive for the DVT, and 228 out of 240 without DVT tested negative Calculate the following False negative Positive predictive value (PPV) What does this PPV mean Negative predictive value (NPV)
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Torsion dystonia is a movement disorder that affects 1 in every 1,000 persons of Eastern European (Askenazi) Jewish descent. What is the carrier frequency for this population?
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Two of the loci identified in the 2019 study were not identified in prior GWAS studies focused on this trait in people of European or African ancestry, and those studies identified some loci not identified in this 2019 study of Hispanic/Latino people. Which of the following statements is the most likely explanation for these discrepancies? O Some of the genes impacting prolonged QRS risk are different in people of different ancestry groups O People of Hispanic/Latino ancestry have a higher overall risk of prolonged QRS The methodology employed in this study was flawed People of Hispanic/Latino ancestry have a lower overall risk of prolonged QRS
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