A researcher was studying a new transcription regulator called UOT and wanted to study its localization by fusing GFP to UOT. When GFP:UOT was expressed in cultured cells, the researcher noticed that the GFP signal was in the nucleus for only some of the cells. Which of the following statements MOST likely explains these results? O UOT has a mutated nuclear localization signal. O UOT localizes to the nucleus when specific signals are in the cytosol. UOT localizes to the nucleus through the endoplasmic reticulum. O UOT only has a nuclear export signal.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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A researcher was studying a new transcription regulator called UOT and wanted to study its
localization by fusing GFP to UOT. When GFP:UOT was expressed in cultured cells, the researcher
noticed that the GFP signal was in the nucleus for only some of the cells. Which of the following
statements MOST likely explains these results?
O UOT has a mutated nuclear localization signal.
O UOT localizes to the nucleus when specific signals are in the cytosol.
O UOT localizes to the nucleus through the endoplasmic reticulum.
O UOT only has a nuclear export signal.
Transcribed Image Text:A researcher was studying a new transcription regulator called UOT and wanted to study its localization by fusing GFP to UOT. When GFP:UOT was expressed in cultured cells, the researcher noticed that the GFP signal was in the nucleus for only some of the cells. Which of the following statements MOST likely explains these results? O UOT has a mutated nuclear localization signal. O UOT localizes to the nucleus when specific signals are in the cytosol. O UOT localizes to the nucleus through the endoplasmic reticulum. O UOT only has a nuclear export signal.
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