A possible important environmental determinant of lung function in children is the amount of cigarette smoking in the home. Suppose this question is studied by selecting two groups: Group 1 consists of 23 nonsmoking children 5−9 years of age, both of whose parents smoke, who have a mean forced expiratory volume (FEV) of 2.1 L and a standard deviation of 0.7 L; group 2 consists of 20 nonsmoking children of comparable age, neither of whose parents smoke, who have a mean FEV of 2.3 L and a standard deviation of 0.4 L. A) Assuming this is regarded as a pilot study, how many children are needed in each group (assuming equal numbers in each group) to have a 95% chance of detecting a significant difference using a two-sided test with α = .05? B) Answer the question in Problem A if the investigators use a one-sided rather than a two-sided test. Suppose 40 children, both of whose parents smoke, and 50 children, neither of whose parents smoke, are recruited for the study. C) How much power would such a study have using a two-sided test with significance level = .05, assuming that the estimates of the population parameters in the pilot study are correct? D) Answer Problem C assuming a one-sided rather than a two-sided test is used.

Calculus For The Life Sciences
2nd Edition
ISBN:9780321964038
Author:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.
Publisher:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.
Chapter13: Probability And Calculus
Section13.2: Expected Value And Variance Of Continuous Random Variables
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A possible important environmental determinant of lung function in children is the amount of cigarette smoking in the home. Suppose this question is studied by selecting two groups: Group 1 consists of 23 nonsmoking children 5−9 years of age, both of whose parents smoke, who have a mean forced expiratory volume (FEV) of 2.1 L and a standard deviation of 0.7 L; group 2 consists of 20 nonsmoking children of comparable age, neither of whose parents smoke, who have a mean FEV of 2.3 L and a standard deviation of 0.4 L.

A) Assuming this is regarded as a pilot study, how many children are needed in each group (assuming equal numbers in each group) to have a 95% chance of detecting a significant difference using a two-sided test with α = .05?

B) Answer the question in Problem A if the investigators use a one-sided rather than a two-sided test.

Suppose 40 children, both of whose parents smoke, and 50 children, neither of whose parents smoke, are recruited for the study.

C) How much power would such a study have using a two-sided test with significance level = .05, assuming that the estimates of the population parameters in the pilot study are correct?

D) Answer Problem C assuming a one-sided rather than a two-sided test is used.

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