A polydactylous, normal-visioned, brown-eyed man with wavy hair has a nonpolydactylous, blue-eyed mother. He proposed marriage to a nonpolydactylous, astigmatic, blue-eyed, and curly-haired lady whose mother has normal vision. However, the lady is worried about the proposal since sickle-cell anemia has been known to run in both their families. a. Is there a genetic basis for her worry? Explain. b. If it turned out that the lady is a carrier and the man has normal RBC, what would be their COMPLETE genotypes? Male genotype: Female genotype:  c. Based on their genotypes, what is the probability that they would have: c.1 a child homozygous for normal RBC? c.2 nonpolydactylous child with normal vision? c.3 polydactylous, astigmatic child and sickle-trait carrier? c.4 a boy with his father’s genotype? c.5 a girl with her mother’s genotype?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section10.7: Defects In Transport Proteins: Hemoglobin
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A polydactylous, normal-visioned, brown-eyed man with wavy hair has a nonpolydactylous, blue-eyed mother. He proposed marriage to a nonpolydactylous, astigmatic, blue-eyed, and curly-haired lady whose mother has normal vision. However, the lady is worried about the proposal since sickle-cell anemia has been known to run in both their families.

a. Is there a genetic basis for her worry? Explain.

b. If it turned out that the lady is a carrier and the man has normal RBC, what would be their COMPLETE genotypes?

Male genotype:
Female genotype: 

c. Based on their genotypes, what is the probability that they would have:

c.1 a child homozygous for normal RBC?

c.2 nonpolydactylous child with normal vision?

c.3 polydactylous, astigmatic child and sickle-trait carrier?

c.4 a boy with his father’s genotype?

c.5 a girl with her mother’s genotype?

 

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