Genetics Question 12 A B C D ETammy and Peter are not deaf, but they have a daughter and a son who are deaf anda son who is not deaf. The family pedigree is shown at the top left of the figureabove. You analyze an autosoaml gene known to be involved in deafness and usetwo PCR primers (blue arrows in the figure below the pedigree) to amplify DNA froma specific exon of the gene (in red). Many alleles of the gene are known to involvedeletions in this exon. You the perform gel electrophoresis on the PCR products fromeach family member. The resulting gel (with negative and positive ends indicated) isat right. Based on thisWhich two lanes (letters) represent the parents?Which tow lanes (letters) represnt the deaf children?Which lane (letter) represents the child who can hear?

Based on the gel electrophoresis results: - The two lanes representing the parents are likely the…

Answered: A B C D E Tammy and Peter are not deaf,…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 14QP

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The figure below represents a two-generation pedigree representing the inheritance of hereditary deafness (HD), which, has been shown to be autosomal recessive. Below the pedigree (and aligned with each person in each generation) are Southern blot gels for two RFLP loci. The BamH1 RFLP locus has alleles of either 7 kb or 5 kb and the EcoRI RFLP locus gives either a 4 kb or 3 kb EcoRI fragment. a. Determine if HD is linked to either of these markers. b. If linkage is detected between HD and one of the RFLPs, are there any recombinant offspring that you can detect? c. If linkage is detected between HD and one of the RFLPs, what is the approximate map distance between the two? Do you think that this distance will efficiently and effectively allow the RFLP to track the HD gene?
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The Figueroa family has a genetically inherited trait called ocular albinism—lack of pigment in the eye—which is caused by a 516-bp deletion in an exon of a single gene. DNA for this gene was amplified from each member of the family and run on the gel shown below. The thickness of the band indicates the relative amount of DNA. Use the pedigree and the gel to determine the most likely mode of inheritance for this disease. a) x-linked dominant b)x-linked recessive c)autosomal dominant d) autosomal recessive e) cant be determined
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The Figueroa family has a genetically inherited trait called ocular albinism-lack of pigment in the eye-which is caused by a 516-bp deletion in an exon of a single gene. DNA for this gene was amplified from each member of the family and run on the gel shown below. The thickness of the band indicates relative amount of DNA. Use the pedigree and the gel to determine the most likely mode of inheritance for this disease. Becky Ben Jasper Lyla Sam Autosomal dominant Cannot be determined Autosomal recessive X-linked dominant X-linked recessive Becky Jasper Lyla Ben Sam
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