5b. When you mutagenize a diploid organism, chances are astronomically high that you will be creating a heterozygote on the spot. Why would your mutation be heterozygous and not homozygous?
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- Discuss the consequences of a germ-line versus a somatic mutation.12 13 14 Which of the following is true of a somatic mutation? A. They are mutations passed on to offspring. B. They occur less often than germline mutations. C. They are mutations in gametes, germ cells or gametocytes. D. They are mutations in cells other than gametes, germ cells or gametocytes. Which of the following best defines a transgenic organism? An organism that has had a portion of its genome deleted An organism that has had a synthetic gene inserted into its genome An organism that has been cross mated with a different organism An organism that has been modified to carry a gene derived from a different organism A. B. C. D. The disease Malaria is caused by Plasmodium. The main structural features of Plasmodium are show below. Nucleus Plasma Membrane Mitochondria K.Quigley 2021 A. Spores. B. Runners C. Binary fission D. Nuclear fusion Polar Ring -Rhoptries Ribosomes From the diagram, what is the most likely method of reproduction used by this organism in the human body?Describe the three general groups of chemical mutagens.
- 9.) Describe the molecular mechanisms of mutagenesis. Consider Inciuding the bases impacted, the relative prevalence, and the relative ease with which the mutation can be repaired for each.Discuss the times in a person’s life when it is most important toavoid mutagens. Which parts of a person’s body should be the mosthighly protected from mutagens?in a paragraph discuss some examples of the effects of chromosomal mutations in humans in your own words.
- 1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Please EXCLUDE the use of CRISPR from consideration. A. Will you use germline or somatic cell gene therapy? Please NAME and DEFINE the form of gene therapy selected, then explain WHY this is the most appropriate choice.1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). a) Hypothetically, what specific type of VECTOR will you use to perform your gene therapy? Please select from the following list of potential vectors: disabled retrovirus, adenovirus, adeno-associated virus (AAV), or herpes simplex virus (HSV), then give two reasons why this specific vector is the most appropriate for your gene therapy. Please explain why you were able to rule out the other potential…1). In the absence of this enzyme, a substance called ceroid lipofuscin accumulates in lysosomes in the brain, resulting in seizures, blindness, decline in cognitive function and motor skills, dementia, and death by the late teens or early 20’s. The TPP1 gene is 6695 bp in length. Think about the characteristics of Batten disease, and then suggest an approach to gene therapy that might be effective for this specific genetic disorder. You may assume that your research team is working in the U.S. and your research is funded by a grant from the National Institutes of Health (NIH). Other scientists have suggested that it might be possible to use CRISPR to treat this genetic disorder in affected individuals. (i) First, what is CRISPR? (BRIEFLY describe what it is and how it works). (ii) Briefly describe how CRISPR could be utilized in treating genetic conditions such as Batten disease.
- 1.B Which of the following processes takes place in the cytoplasm? - DNA replication - transcription -intron removal -translation -primary mRNA splicing 1.C For a DNA strand that is two nucleotides long, how many different sequences are possible? -2 -4 -8 -16 -64 1.D Which of the following is mismatched? A)physical expression of a trait - phenotype B)allele that masks the expression of an alternate allele - dominant C)identical alleles - heterozygous D)allele whose expression can be masked by an alternate allele recessive E)the specific alleles that an individual has - genotypediscuss what is mutagenesis and what mechanisms are invloved?Explain why, in humans, chromosomal mutation rates in females are much higher than in males.