(56) A 1 year old boy dies of staphylococcal pneumonia. He has had multiple skin infections since birth. Separation of the umbilical cord was delayed. A skin window test was performed and no leukocyte accumulated on the cover ship. The cytometric analysis showed that only 5% of the T lymphocytes reacted with a monoclonal antibody to leukocyte functional antigen-1 chain (CD 18) compared with reactivity of 62 % for a normal subject. Just prior to death, his leukocyte count was 75,000/mm3. Which of the following is the most likely diagnosis? (A) AIDS

(56) A 1 year old boy dies of staphylococcal pneumonia. He has had multiple skin infections since birth. Separation of the umbilical cord was delayed. A skin window test was performed and no leukocyte accumulated on the cover ship. The cytometric analysis showed that only 5% of the T lymphocytes reacted with a monoclonal antibody to leukocyte functional antigen-1 chain (CD 18) compared with reactivity of 62 % for a normal subject. Just prior to death, his leukocyte count was 75,000/mm3. Which of the following is the most likely diagnosis? (A) AIDS

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter16: Antifungal, Antiviral, And Immunizing Agents

Section: Chapter Questions

Problem 20RQ

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142. A 1-year-old boy has had recurrent pyogenic infections of the skin and upper respiratory tract. His brother died at the age of 6 months from an undiagnosed infection; his sister appears healthy. Laboratory studies of serum show: IgG IgA, IgM Peripheral lymphocytes 120 mg/dL undetectable 80% T lymphocytes, <1% B lymphocytes Which of the following findings is most likely on examination of tonsillar tissue? OA) Absence of lymphoid follicles and germinal centers B) Absence of macrophages C) Decreased cellularity of the parafollicular cortex D) Hyperplasia of endothelial cells lining lymphatic sinusoids E) Increased numbers of eosinophils and plasma cells
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