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54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin ea drug (Dramamine) is to be designed along me following lines. The drug is dissolved in a hin gelatin film and applied as a "patch" to the kin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 10-7 cim²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54

54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin ea drug (Dramamine) is to be designed along me following lines. The drug is dissolved in a hin gelatin film and applied as a "patch" to the kin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 10-7 cim²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54

Introduction to Chemical Engineering Thermodynamics
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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4.54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin sea drug (Dramamine) is to be designed along the following lines. The drug is dissolved in a thin gelatin film and applied as a "patch" to the skin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 107 cm²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54
Transcribed Image Text:4.54 A sustained-release system for an antinau- gelatin is sandwiched between two very thin sea drug (Dramamine) is to be designed along the following lines. The drug is dissolved in a thin gelatin film and applied as a "patch" to the skin, much like a Band-Aid (see Fig. P4.54). The polymeric membranes that offer no resistance to passage of the drug. The drug is not volatile in the surrounding air. The diffusivity of Dra- mamine in the gelatin is 3 x 107 cm²/s. Find the gelatin film thickness such that 90% of the Dramamine is delivered to the skin over a 3- hour period. Assume that the skin region is so highly vascularized that the Dramamine concen- tration is practically zero in the skin and tissue beneath the patch. Film Skin Figure P4.54
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