4. Which protein(s) from the list above bind(s) to regulatory switches in a sequence-specific manner? ☐ proteasomes general transcription factors lactase ☐ activators ribosomes DNA polymerase ☐ mediators RNA polymerase ☐ operons
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Part 1 Bio Question 4
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- 1. a)how is it possible for such drugs to selectively kill bacterial cells and not our own cells? b)Provide an example of post-translational regulation of protein activity and explain the advantage of regulating each protein/process at the post-translational level instead of the transcriptional level.4. The strength of ligand-protein binding is a property of the binding site called --------------3.) How do cis-acting regulatory elements and trans-acting regulatory proteins act in coordination to regulate gene expression?
- 1. Search for the `P06858` a) Give information about the PTM and Processing of this protein. b) Which position has maximum amount of variations? Give details about the variations. (Eg: What kind of variation? Feature ID? Disease association? etc..)4. What is the use of miRNAs in the cell? Please discuss the effect of a mutant Argonaute protein on the function of a particular miRNA?1. Discuss how cholesterol is transported between tissues in plasma lipoproteins. 2. When a gene is being transcribed, the nitrogenous base code must be made available for reading by polymerizing enzymes. Discuss where it begins?
- 1. The specific sequence component of the bacterial promoter located 10 base pairs upstream of the bacterial gene start site is called?1. Why aren't ssb proteins necessary in transcription?4 the two factors that bind directly to the DNA at specific sequences are TFID and TFIIB, in genreal terms what is the function of each of these two transcription factors in the initiation of transcription?
- 1. What is the central dogma? What are the compounds involved in this process? (Keywords: transcription of DNA to RNA, translation of RNA to proteins; gene expression)1. Why is RNA necessary to act as a messenger? Why can't the code be taken directly from the DNA? How do some cells become brain cells and others become skin cells, when the DNA in ALL the cells is exactly the same? In other words, if the instructions are exactly the same, how does one cell become a brain cell and another a skin cell?7) Please propose a mechanism that may link the increased abundance of unfolded proteins(perhaps due to elevated temperatures) with increased ability of the cell to facilitateprotein folding. The mechanism should involve a sequence of multiple events.