Examples of X-linked recessive disorders:• Red-green color-blindness• Hemophilia (fig. 92)• Duchenne muscular dystrophy (DMD)Father hashemophilia XYMother is not a carrierof the hemophilia gene XXFather does notMother is a carrierhave hemophilla XYof the hemophilia gene XX50% chancedaughters will be a carrierof the hemophilia gene XX50% chancesons will havehemophilia XY0% chancesons will have100% chancedaughters will be a carrierof the hemophilia gene XXhemophilia XYDoes not haveKey HemophilaHas HemophiliaCarrier of theKeyDoes not haveHermophiliaCarrier of theHemophilia geneHas HemophiliaHemophilia geneabFig. 92. Inheritance of hemophilia or bleeder's disease (a) when motheris a carrier, and (b) when father has the condition. 4. What mode of inheritance is shown in thepedigree chart on the left? Justify youranswer.5. Construct pedigree charts using the inheritance of hemophilia in figure92 (page 113). This is X-linked inheritance so you are required to labelXX for females and XY for males. The gene responsible for the trait isrepresented by the superscript which should be specified in the legend.

Name: Examples of X-linked recessive disorders:• Red-green color-blindness•
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Description: Examples of X-linked recessive disorders:• Red-green color-blindness• Hemophilia (fig. 92)• Duchenne muscular dystrophy (DMD)Father hashemophilia XYMother is not a carrierof the hemophilia gene XXFather does notMother is a carrierhave hemophilla XYo

Pedigree is a branching representation indicating family members of everi generation . Pedigree…

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4. What mode of inheritance is shown in the pedigree chart on the left? Justify your answer. 5. Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.

4. What mode of inheritance is shown in the pedigree chart on the left? Justify your answer. 5. Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 1QP: The gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show...

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1. Study the given alleles. Write the correct phenotype for each genotype. X – normal Gen otype xC - Color-blind Phenotype XX XY XXC xCY 2. Study the given alleles. Write the correct genotype for each phenotype. xH - Hemophiliac Phenotype X- normal Gen otype Hemophiliac female Hemophiliac male Normal female carrier of the gene Normal male Normal female 28 3. Determine the genotype and phenotype of the offspring. A color-blind mother (XCx) married a normal sighted (XY) father. Genotype: Phenotype: Genotype: Phenotype: Genotype: Genotype: Phenotype: Phenotype: a. There are b. There are c. There are d. There are % normal sons. % normal daughters. % color-blind sons. % color-blind daughters. % normal female, carrier of the disorder. or or or or e. There are or
tion 8: below is the pedigree of inheritance of phenylketonuria (PKU). We will designate the letter Caven for the dominant allele and "p" for the recessive allele. 4 The pedigree shows that the pattern of inheritance for the allele for phenylk ylketonuria is: I. II. 1 III. IV. Autosomal dominant Autosomal recessive X-linked dominant X-linked recessive b. The parents in generation I have how many children: I. 3 Boys II. 3 Girls III. IV. 3 Boys and 1 Girl 3 Girls and 1 Boy c. What is the genotype of individual 1 in generation III: I. PP II. pp III. Pp " O 1 III. 50% E III 1 ▬ 2 2 IV. 25% 1 3 IV. Can be PP or Pp ii. Suppose that a man having type AB blood marries a woman having type O blood. What is the probability that their child will have type A blood? I. 100% II. 75% 2 4 3
1. Why did the royal family have an issue with the hapsburg jaw/lip? 2. Was it an Autosomal or X-linked Genetic Disorder? 3. Dominant or Recessive?(Explain) Using a Punnett Square predict what the Genotypes are for the persons II-3 & II-(* C/C or C/A mean that they married and had children with a blood cousin).
Pedigree 2: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B State the genotypes of individuals # 1 #4. C If individual #3 has another daughter with the same partner, what is the probability that this daughter will be affected (show the disease)?
2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.
Let us practice it again! Analyze the pedigree below to answer the questions that follow. Huntington's disease a disorder in which nerve cells waste away, or disintegrate, is passed down through families. certain parts of the brain Huntington's diseate llustration ereated in htps://pregenygenetion.com/ 1. What members of the family above are affected with the Huntington's disease? 2. Tnere are no carriers ior Huntungton's disease you either have it or you do not. Is Huntington's disease caused-by a dominant or recessive trait? 3. Identify the genotypes of the following individuals using the pedigree above. (homozygous dominant, homozygous recessive, heterozygous). I- 1 II -1: II -3: III - 4 : 4. How many children did individuals I-1 and I-2 have? 5. How many girls did II-1 and II-2 have? How many have Huntington's Disease? 6. How are individuals III-2 and II-4 related? I-2 and III-5?
Complete the following queatione BEFORE ATTEMPTING THE HW 1 BLACKBOARD ASSIGNMENT, In the following human pedigrees, the filled symbols represnent the affected individuals who suffer from the disease. Use A/a to represent alleles for autosomal traits and XIX/Ytorepresent alleles for X-linked traits. Use the uppercase letter to represent the dominant allele and the lowercase letterto represent the receasive allele. afected fomale Unafected female affected male Unaffected male Pedigree 1: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B. State the genotypes of individuals #1-#3. C. What is the probability that individual #4 is a carrier of this disease if his mother is homozygous dominant and his father is heterozygous? Pedigree 2: What is the most likely mode of inhentance of this disease? Choose from: autosomal dominant, autosomal recessive X-linked dominant X-linked recessive.…
6. Identify the mode of inheritance for the following pedigree. Provide the genotypes of indicated individuals. ? Genotypes: Il-1 IV-1 V-6 Il-2 IV-2 V-12 Il-3 IV-3 V- 14 III-1 IV-4 V-16 III-13 V- 1 V-19
3. The recessive sex-linked gene (h) prolongs the blood-clotting time, resulting in the genetically inherited disease called hemophilia. From the information in the pedigree chart (right), answer the following questions: Hemophilia in humans (a) If 112 marries a normal man, what is the probability of her first child being a hemophiliac? 2 (b) Suppose her first child is actually a hemophiliac. What is the chance that her second child will be a boy with hemophilia? 2 (c) If I14 has children with a hemophiliac man, what is the probability that her first child will be phenotypically normal? (d) If the mother of 12 was phenotypically normal, what phenotype was her father? 4. The phenotypic expression of a dominant gene in Ayrshire cattle is a notch in the tips of the ears. In the pedigree chart on the right, notched animals are represented by the solid symbols. Ear notches in Ayrshire cattle Determine the probability of notched offspring being produced from the following matings: 1 2 (a)…
1. The pedigree below shows the incidence of rare, autosomal dominant disorder called Ehlers-Danlos disease. The pedigree covers three generations of a particular family and also shows individual genotypes at a potential marker locus (M). a) Indicate the phase of all gen II and III individuals. DdM1M3 ddM2M6 II DDM3M6 ddM4M5 III DdMзM4 DdMЗМ5 DDM3M4 ddM3M5 DDM3M4 ddM5M6 DDM3M4 ddM4M6 ddM5M6 ddM5M6 b) Which, if any, of the gen III individuals are recombinants? c) Calculate the LOD score as a test of physical linkage between the marker (M) and the disease locus. d) What do you conclude about linkage between D and M?
Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.
1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour…