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- Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the acetolactate synthase and phosphoketolase reactions (shown here) is similar to that of the transketolase reaction (Figure 22.30). Write suitable mechanisms for these reactions.Based on your residing of this chapter, what would you expect to be the most immediate effect oil glycolysis, if the steady-state concentration of gJucose-6-P were 8.3 mM instead of 0.083 mM?The Relative Efficiency of ATP Synthesis in Noncyclic versus Cyclic Photophosphorylation If noncyclic photosynthetic electron transport leads to the translocation of 7 H+/2e- and cyclic photosynthetic electron transport leads to the translocation of 2 H+/e-, what is the relative photosynthetic efficiency of ATP synthesis (expressed as the number of photons absorbed per ATP synthesized) for noncyclic versus cyclic photophosphorylation? (Assume that the CF1CF0-ATP synthase yields 3 ATP/14 H+.)
- Comparing Glycolysis Entry Points for Sucrose Sucrose can enter glycolysis by either of two routes: Sucrose phosphorylase: Sucrose + Pi fructose + glucose-1-phosphate Invertase: Sucrose + H20 fructose + glucose Would either of these reactions offer Jin advantage over the other In the preparation of hexoses fur entry into glycolysis?2. The overall result of CH,OH + 2 NAD+ + 2 NADH glycolysis can be summarized by the equation on the right in which HO the glucose origins of the carbon atoms in pyruvate are color coded. Show by writing the reactions catalyzed by aldolase and triose phosphate isomerase and num- bering the carbons why this is the fate of glucose carbon atoms in pyruvate. Indicate numbering of carbons in Glucose-6-Pi, Fructose-1,6-BisPi, enzyme products, and pyruvate. HO + 2 Pi 2 + 2 ATP > OH + 2 ADP (CH3 + 2 H20 Glucose Pyruvate1. Identify the oxidized coenzyme (letter abbreviation only) that participates in this reaction of the Kreb’s cycle. Succinate --> Fumarate 2. How many mol of NADH can be obtained upon the beta oxidation of stearic acid? 3. How many mol of ATP can be obtained upon the complete oxidation of 1 mol stearic acid? 4. How many steps in glycolysis in which ATO is converted to ADP?
- 6. Malate dehydrogenase catalyzes the following reversible reaction: COO- HO-C-H CH₂ COO™ L-Malate NAD+ y malate NADH + H+ dehydrogenase COO- 0=C CH₂ COO™ Oxaloacetate AG'° = 29.7 kJ/mol Malate + NAD+→NADH + H+ + oxaloacetate Calculate AG" and the ratio or products and reactants for the malate dehydrogenase reaction to proceed from left to right as shown. (The Faraday constant. 3, is 96.48 kJ/V-mol; RT(37°C)= 2.58kJ/mol) Steps: 1. Explain how you determined which molecule is an electron donor Malate and which is an acceptor NAD*. -2- 2. Calculate AED (write equation, then show calculations, for standard reduction potentials (E_values) see table in the posted lecture) 3. Calculate AG (write equation, then show calculations) 4. Calculate the ratio of products and reactants needed to for Malate + NAD+→→NADH + H+ + oxaloacetate reaction to proceed forward (write equation, then show calculations)2. Lactate dehydrogenase (LDH) catalyzes the reaction Ο ()) 0 NADH + H* NAD+ C=0 HO-C-H CH₁t Pyruvate lactate dehydrogenase CHa L-Lactate AG 25.1 kJ/mol which represents one of the metabolic fates of pyruvate, the end product of glycolysis. The positioning of the sub-strate pyruvate in the active site of lactate dehydrogenase is shown on the right. NADH (nicotinamide adenine dinu- cleotide) is a cofactor in the reaction and provides a hydride anion H (highlighted with light blue) through direct transfer to reduce the carbonyl group of pyruvate. (a) ( Gln 102 Arg109 NH2 NH Thr246 H₂C-C-OH HN NH H CHS H H H. His 195 NH Pyruvate N-(NADH) H H CH3 H HN H NH H₂C-C-CH₂ Пle250 Asp168 NH Arg171 ) Compare the mechanism of the LDH reaction, as implied by the diagram above, to that of a-chymotrypsin with respect to the oxyanion hole, conversion of the substrate carbonyl group having sp² hybridization to sp³ hybridization, the attacking nucleophile, and residues achoring the substrate in the active…asap
- Match the name of the process with its description Electron transport chain oxidation of pyruvate chemiosmotic phosphorylation citric acid cycle 1. The 2-carbon acetyl group separates from coenzyme A and attaches to a four carbon molecule called oxaloacetate, forming the 6-carbon molecule called citrate. In a series of enzyme-catalyzed steps, the citrate loses 8 high-energy electrons to NAD+ and FAD. In addition, ADP is phosphorylated (changed to ATP) as part of step three. Carbons leave as carbon dioxide in steps 2 and 3. This leaves a 4-carbon molecule, which eventually combines with another Acetyl CoA to form citrate and the cycle begins again. 2. Pyruvate moves into the mitochondrion and two electrons are removed from pyruvate and transferred to NAD+. One of the carbon atoms in pyruvate leaves as a molecule of carbon dioxide. The remaining 2-carbon piece becomes attached to Coenzyme A. 3. Protons concentrated in the…Given what you know about the involvement of nicotinamide nucleotides inoxidative and reductive metabolic reactions, predict whether the followingintracellular concentration ratios should be 1, > 1, or < 1. Explain youranswers.(a) [NAD+] >[NADH](b) [NADP+] >[NADPH](c) Since NAD+ and NADP+ are essentially equivalent in their tendency to attract electrons, discuss how the two concentration ratios might bemaintained inside cells at greatly differing values.21) Compute the moles of FADH2, NADH, GTP generated and NADPH consumed in the dissimilation of one mole each of the octadecanoic acid and A3.5-ocatadienoic acid thioesters shown below to CO2 in the mitochondrial matrix space. Enter the product yields of electron carriers and GTP and the total yield of ATP after processing mitochondrial electron-transport chain in the tables provided below COAS COAS Product Total Converslon Yield ATP Product Total Conversion Yleld ATP FADH2 1.5 FADH2 1.5 2.5 NADH 2.5 NADH NADPH -2.5 NADPH -2.5 GTP GTP Total ATP Total ATP 8.