3. Determine two of the possible starting material pairings that would give the product below using a Suzuki cross-coupling reaction. Recall that the Suzuki coupling is suitable for coupling both aryl and vinyl groups (to connect 2 different sp² carbon groups). 2 pairs of possible starting materials

3. Determine two of the possible starting material pairings that would give the product below using a Suzuki cross-coupling reaction. Recall that the Suzuki coupling is suitable for coupling both aryl and vinyl groups (to connect 2 different sp² carbon groups). 2 pairs of possible starting materials

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter16: Synthesis Workshop 1

Section: Chapter Questions

Problem 32CTQ

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[Review Topics] [References] Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C CH3 H2O NaOH • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Nat, I', in your answer. • In cases where there is more than one answer, just draw one. C opy aste C. Previous Next Email Instructor Save and Ex Cengage Learning | Cengage Technical Support 5:48 PI 82°F 3/28/20
2) For the following reaction, draw the likely nucleophilic substitution mechanism and try to write out that mechanism in words as in the previous example. CI OH OH2
Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C HCI / H2O `NH2 reflux • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na", I, in your answer. • In cases where there is more than one answer, just draw one. opy aste Previous Next
The first reaction can lead to over substitution. In the second reaction, no over substitution is observed. In 4 sentences or less, provide a reasonable explanation for this observation. AICI3 over substitution product AICI3
4) Vocabulary: words are given circle the correct one. a. A Robinson Annulation can occur with acetoacetate / malonic ester / both / neither Fill in the blanks with the appropriate vocabulary word. If two as the nucleophile, and with conjugated ester / conjugated ketone / epoxide / all/ none as the electrophile. The Robinson Annulation is a reaction followed by a reaction and always / sometimes / never gives a 6-member ring. b. It is always / sometimes / never possible to use base to form an acyl anion directly from an aldehyde. c. True / False.Aliphatic heterocycles typically react like linear versions of the functional group. d. Claisen condensations require catalytic / 1 equivalent / large excess base, at least 2 alpha hydrogens on the nucleophile, always / sometimes / never use an ester as an electrophile, and always / sometimes / never use an ester as a nucleophile. e. Reaction of a beta-ketoester with water, acid, and heat gives first a reaction, then and lastly This reaction…
2. Complete the table below indicating what is important in each category for an E1 or E2 reaction. E1 Rate Law Best Solvent Alkene geometry outcome How does electrophile substitution affection the reaction? Does leaving group ability affect the rate? Does base strength affect the rate? Does/how does base type affect product structure? E2
e 2. Draw the structures and explain why CH3CH₂O and CH3CO₂ are good nucleophiles but CH3SO3, water, and alcohols (R-OH) are poor nucleophiles. Propose a 'cutoff for the amount of negative charge needed to be a good nucleophile. CH3CH₂O CH3CO₂ CH3SO3 H₂O CH3OH
Chemistry Please help explain this textbook question: Although N, N -dimethylaniline is extremely reactive toward electrophilic aromatic substitution and is readily substituted by weak electrophiles, such as diazonium and nitronium ions, this reactivity is greatly diminished by the introduction of an alkyl substituent in an ortho position.
Why is concerted syn addition needed in the first step of X2 addition or mercurinium formation? 1.Syn addition occurs on both sides of the alkene bond to prevent cation formation and create a lower 2.energy interemdiate. 3.The alkene attacks the X2 from the top and bottom faces equally. 4.Only one face of the alkene can interact with the reagent. 5.No answer text provided.
Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C. ... NH2 HCI/H₂O reflux • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na+, I, in your answer. • In cases where there is more than one answer, just draw one. + 4 n [ ?
When the depicted alkyne is treated first with sodium amide and then with the alkyl halide shown, one of the depicted products is formed Circle the correct product and write the steps in the mechanism that show how this reaction occurs to form the product you selected. Add the following A. all necessary curved arrows B. the structure of any intermediates that are formed during the mechanism, including stereochemistry C, what, if anything, is added or lost during each step of the mechanism, D any nonzero formal charges. Only use materials those that are given in the equation.
2. The intermediate in the following nucleophilic aromatic substitution reaction has at least 5 resonance structures. For this question, complete the following tasks: a. Show the mechanistic arrow(s) for the first step. b. Draw TWO of the many resonance structures of the intermediate, drawing out the -NO₂ groups in each. c. Draw the neutral product. يمهم NO₂ NO₂ HO and others neutral product