3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina

3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina

EBK A SMALL SCALE APPROACH TO ORGANIC L

4th Edition

ISBN:9781305446021

Author:Lampman

Publisher:Lampman

Chapter45: Preparation Of Indigo

Section: Chapter Questions

Problem 1Q

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