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- 1.A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement. 2.Which of the following antibody classes or isotypes facilitate the sequential binding of the C1, C4, C2, and C3 components of the complement system? A. IgAandIgD B. IgAandIgE C. IgDandIgM D. IgE and IgG E. IgMandIgG6. Match the example/scenario provided to the type of humoral immunity. a. active, naturally acquired b. active, artificially acquired mak c. passive, naturally acquired d. passive, artificially acquired Recent research has shown promise in the treatment of stomach cancer. Patients given a monoclonal antibody that binds to the cancer cells, elicits the immune response to kill the cancer cell. What type of immunity is this an example of? Timothy, a three-year-old, was playing on the playground when he picked up a piece of chewed gum an adult had thrown on the ground. The next day, he ran a fever and was vomiting which his mom attributed to him picking up of immunity is this an example of? the gum and eating it. Assuming this is true, what type In 1950-1960, a vaccine to combat polio was developed. Two types of vaccines were created, an oral vaccine that contained live attenuated (less disease causing) virus and later an inactivated polio vaccine. What type of immunity is this an example…1. When encountering antigen, describe the mechanism of antigen presentation by B cells. 2. Compare / contrast the advantages and disadvantages of active immunity with passive immunity. 3. Does antibody directly destroy a microbe? EXPLAIN. 4. Use the following terms to construct a coherent mechanism for cell mediated immunity: Interleukin, perforin, CD4 cells, CD8 cells, dendritic cells, MHC class I and class II 5. Upon invasion by a microbial antigen with multiple epitopes (antigenic determinants), What makes clonal selection for T cells and B cells relevant? 6. Why have different classes of antibodies (i.e. IgD, IgE)? 7. Why is the primary and secondary responses to antigen important for the host and for clinical diagnosis? 8. Are all adaptive immune responses the same? EXPLAIN.
- 1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv1Explain and describe about the structure of antibodies 2)explain and describe about the significance of antibodies 3)why is beneficial to have both types of responses (non-specific defence and specific defence16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?
- 1. Match the type of hypersensitivity reaction with their cause. Type IV hypersensitivity reaction Type II hypersensitivity reaction Type III hypersensitivity reaction A. Effector T cells specific for the sensitizing Ag B. Immune complexes formed from IgG binding to soluble Ag C. Antibodies specific for altered components of human cells 2. Because the FceRI receptors on mast cells, basophils and eosinophils always have IgE bound, they have Ag-specific receptors that function similar to B and T cells. Of the following list of characteristics, which ones are unique to Mast cells, basophils, and eosinophils? Choose all that apply. A. Binding antigen triggers differentiation B. Many different IgEs can be found on the surface of one cell C. All of the IgEs on the surface of a…44. Which of the following is not true of the results of antigen-antibody binding? O Agglutination reducing the number of infectious particles to be phagocytosed Neutralization preventing toxins & viruses attaching to cellular receptors; and microbes from attaching via adhesins to mucosal surfaces Lysis (MAC), via activation by antibodies of all 5 immunoglobulin classes, of complement in the Classical pathway of complement activation, Antibody dependent cell-mediated cytotoxicity permitting natural killer (NK) cells to recognize & kill antibody coated cells; & eosinophils to attack worms with attached IgE. All of the above are trueDescribe immunity providing at least 4 examples of clients who may have low levels of Immunitg
- A. In table form, differentiate Primary from Secondary Immune Response according to the ff. a. type of Ig b. action of memory cells c. amount and speed of antibody production d. recognition phase e. timing of exposure B. In table form, differentiate Cell mediated from Antibody mediated (humoral) Immunity according to type of cells involved and product form C. Enumerate 5 lab tests/procedures done to obtain/identify Lymphocytes. Then briefly discuss one.36) Autoantibodies associated with thrombosis in systemic lupus erythematosus are() A Anti-Sm antibody B Anti-SSA antibody C Anti-cardiolipin antibody D Anti-dsDNA antibody E Anti-nRNPantibody1aDiscuss three differences between antigen and antibodies b Explain the structure of the antibody molecule. c Discuss the differences between humoral and cell mediated immunity in terms of chemicals and cells involved in each process as they tackle pathogens.