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- 1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…1. Dosage of drugs. 2. Hypnotics. 3. Give a pharmacological characteristic for the following drugs: •Clopheline •Zopiclone • Interferon1. What is the drug target?
- 7. What are the determinants for drug liposolubility?35. A patient is exhibiting severe anxiety associated with a 3-year struggle with colon cancer. The primary health- care provider prescribes gabapentin (Neurontin) 100 mg three times a day for the anxiety. The primary health-care provider indicates that the oral solution form of the drug be dispensed because the patient has difficulty swallowing tablets. The gabapentin solution states that there are 250 mg/5 mL. How much solution should the nurse administer? Record your answer using a whole number. Answer: mL7. (a) Discuss the drug-receptor interaction with necessary illustration.
- 5. Define asthma, write the pharmacology of anti-asthamatics.1.- Please name the drug sources, and explain one of them. 2.- Why are important the Drug Standards? 3.- What means: PDR and USAN? 4.- Please explain the Controlled Substances Act of 1990. 5.- What is the Food Allergen Labeling and Consumer Protection Act of 2004? Why is important? Please give an example of one product label. 6.- What is Pharmacokinetics? What means excretion of a drug? 7.- Which factors can change the drug absorption? 8.- Please name the factors that can affect the Drug Action, and explain one of them. 9.- What is an adverse reaction? 10.- What is a palliative drug?1. Relationship of Drug solubility & dissolution rate on Physico-Chemical Properties 2. Relationship of Particle size & effective surface area on Physico-Chemical Properties