2. At the end of the extraction lab that you will conduct in a few weeks, you wll repeat this TLC experiment. Your task that day will be to use extraction to separate a mixture of benzoic acid, 2-naphthol, and 1,4-dimethoxybenzene. Explain how TLC could be used to demonstrate successful separation of a mixture into individual compounds.
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- After a complicated chemical synthesis, the last step is to separate two liquids, ACETONE AND ANILINE. What separation method should you use? (Feel free to access the SDS for the two compounds). Be specific about the exact type of separation you choose and explain why.According to the following TLC, choose all compounds that are present in the crude sample, before recrystallization? 1 methyl benzoate 2 triphenylmethanol 3 a non-polar impurity such as biphenylHow can you use TLC to determine if a chemical reaction has gone to completion? For example, treatment of cyclohexanol in the presence of a non-nucleoplhilc acid, sulfuric acid gives the corresponding alkene, cyclohexene via an E1 reaction. Draw 3 examples of TLC plates: a) at the beginning of the reaction, b) during the reaction, and c) at the completion of the reaction. Explain what is shown on each plate. Hint: What are the dominant intermolecular interactions of cyclohexanol and cyclohexene?
- 7. A student gets the following results after running a TLC plate of several over the counter analgesics. What should the student do to get better results? O Run the TLC for a longer time. O Co-spot the sample several times. Run a new TLC plate in a less polar solvent. O Run a new TLC in a more polar solvent mixture.Khan performed a normal phase chromatography to separate the components of an extract. He then created another chromatogram using the same stationary and mobile phase to analyze known compounds. The chromatograms are shown below. Spot 6 O Spot 5 Spot 4 O Spot 3 Spot 2 Spot 1 Which of the following is TRUE? Sample Extract O Spot 6 is the most polar of the spots. Spot 5 is the same as Compound B. Known Compounds Compound A is more polar than Spot 4. Spot 1 is the most non polar of the spots. Compound C Compound B Compound AN1. Which of the following molecule pair(s) could be potentially distinguished by TLC analysis?
- A student use the same protocol as in the lab manual to extract 4 chloroanilline, benzoic acid and naphthalene. Below are the steps he took Step 1 - Dissolve all three in 15 ml ether and place in separatory funnel Step 2- Add 15 ml of hydrochloric acid and mix well Step 3 - Isolate the aqueous layer and add sodium hydroxide which resulted in a precipitate Step 4- Add 15 ml of sodium carbonate to the ether layer and mix Step 5- Isolate the aqueous layer and add hydrochloric acid, which resulted in a precipitate. Step 6- dry the ether layer and collect the solid that is leftWhich of the compounds would have the shortest retention time on a non-polar GC column? OH HO Hydroxymethyl- cyclohexanol MW: 114 bp: 183 2-Hydroxyethyl- cyclohexanol MW: 144 Methylcyclohexane Methylacetate MW: 98 bp: 101 mp: -127 d: 0.77 MW: 74 mp: -43 d: 0.93 bp: 270 mp: not available d: 0.98 bp: 57 mp: not available d: 0.98 Compound 4 Compound 2 Compound 3 Compound 11. Answer true or false for each statement: a) A TLC analysis is sufficient to characterize the purity of a compound. b) Carboxylic acids containing six or more carbon atoms per molecule are more soluble in2.5 M sodium hydroxide than in diethyl ether. c) Phenols containing six or more carbon atoms per molecule are more soluble in 2.5 M sodium hydroxidethan in diethyl ether. d) Benzoic acid and p-nitroaniline form water-soluble salts, whereas naphthalene does not. e) TLC analysis is the method of choice to determine the type of solid phase and eluent system that is required for a column chromatography separation. f) Mineral oil is an inappropriate heating fluid for determining the boiling points of samples that exceed 200°C (760 torr)? g) A heating bath containing mineral oil should not be used to determine the melting points of solids meltingabove 200 °C
- Qs4. This is a TLC analysis of 3 individual compounds. The plate was run in 20 % ethyl acetate, 80% hexane solvent mixture (eluent). Draw a schematic TLC plate for the same compounds, but when the eluent is 40% ethyl acetate, 60 % hexane. Indicate, what is the most polar and least polar compound (A, B, or C) -- A B CThe purpose of this experiment is to use both extraction and crystallization techniques to separate a solid mixture of organic compounds. You will receive a packet with 1 g of a unknown (pH is basic) amide solid sample which will contain three components, one from each group: Group 1 (~50% wt): ethyl 4-aminobenzoate, ortho-toluic acid, or benzoic acid Group 2 (~40% wt): fluorene, 1,4-dibromobenzene, benzil, benzoin Group 3 (~10% wt): fluorene, 1,4-dibromobenzene, benzil, benzoin (but not the same as Group 2 compound) Create a lab procedure that will allow you to successfully isolate, purify, and identify the two major (Group 1 and Group 2) components of the unknown amide sample. reagents that can be used are 1M HCl, 6M HCl, 1M NaOH, 6M NaOH, diethyl ether, and methylene chlorideSo I completing a lab report and one of the sections is on TLC analysis. In the experiment, the TLC plate was submerged in toluene ethylacetate and had spots of cinnamon leaf oil, cinnamon aldehyde, and cinnamon bark oil. 9 spots total were seen under the UV light, but different spots appeared following a vanillin stain. Why is this so and what does this mean?