2) Identify the reagents you would use in order to synthesize the compound below via an imine formation reaction. Insert a single reagent in each box below. [H+]
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- Rimantadine is an antiviral drug used to treat people infected with life-threatening influenza viruses. Identify the starting ketone that would be necessary in order to prepare rimantadine via a reductive amination. NH2 RimantadineWhen cyclohexanone is heated in the presence of a large amount of acetone cyanohydrin and a small amount of base, cyclohexanone cyanohydrin and acetone are formed. Propose a mechanism.1. Which of the following amines would make an imine if reacted with an aldehyde or ketone? A B e. Which of the following moleculo C NH₂ AN D
- Select the appropriate reagent and TWO possible substrates for the following reductive amination.Following are two possible retrosynthetic analyses for the anticholinergic drug cycri- mine. Fill in the details of each potential synthesis. O: OH + H. Cycrimine (гасemic)Propose preparative routes to the following ketones using an enamine intermediate - you must make the bond in red.
- The ketone whose 1H NMR spectrum is shown here was obtained as the product of an acetoacetic ester synthesis. What alkyl halide was used in the synthesis?Describe the given synthetic pathway. Discuss type of reactions involved, the purpose of each reagent, and the relevance of each step. Provide brief explanation. Create a retrosynthetic map for the synthetic pathway in Question 1.Using ChemDraw, propose a synthetic pathway for the preparation of the compound shown below starting from a primary amine. Your answer does not require a mechanism; you are only required to show the various intermediates formed, along with the key reagents/conditions used.) Br- ?
- 1. What reaction involving amines is required to produce N-Propylcycloheptanamine? Propose a synthesis and mechanism2. Is the reaction below favorable or unfavorable? State your reasons.Describe the given synthetic pathway. Discuss type of reactions involved, the purpose of each reagent, and the relevance of each step. Create a retrosynthetic map for the synthetic pathway in Question 1.Show how to synthesize the following amines from the indicated starting materials below. Each of the final products may require several sequential steps. Draw the structure for each of the steps and show the reagents required. Starting material Final product b) Benzene m-bromoaniline c) ethylbenzene p-ethylaniline + o-ethylaniline d) benzene p-bromoaniline + o-bromoaniline