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- What are the physiochemical properties of terazosin? With illustrationSuggest the effects of each of the following mutations on the physiologicalrole of chymotrypsinogen:(a) R15S(b) C1S(c) T147SAbout cardiotonic glycosides, based on a digoxin structure in the image: Classify the α,β-unsaturated lactone present in digoxin. What is the mechanism of the pharmacological action of digoxin, explain in detail?
- Trelstar® is an injectable formulation of polylactide-co-glycolide (PLGA) microspheresencapsulating triptorelin palmoate (Mw 13115 Da), a synthetic decapeptide agonist analog ofgonadotropin releasing hormone (GnRH). The medicine is used in treatment of patients withprostate cancer. The pharmacokinetics of triptorelin palmoate as free drug follows a 3 compartmentmodel with drug half-lives estimated to be 6 minutes, 45 minutes, and 3 hours, respectively. Threedifferent dosing intervals of Trelstar® are available in clinic: 1 month (3.75 mg), 3 month (11.25mg) and 6 month (containing 22.5 mg of drug).Discuss how encapsulation into PLGA microspheres improves patient therapy with triptorelinpalmoate, and how three dosing intervals available in clinic may have been achieved bymodifications in the formulationHow was thermal stability measured in this paper and describe how GRL-1720 and 5h affect the thermal stability of Mpro and which drug has the larger effect? https://www.nature.com/articles/s41467-021-20900-6Unbranched homopolymer of N-acetyl glucosamine is : 1.Cellulose 2.Chitin 3.Curcumin 4.Concanavalin A