18. You created a transgenic mouse in which all B cells express heavy and light chain of immunoglobulins specific to chicken ovalbumin (OVA). The mouse also expresses the gene for OVA in peripheral tissues (skin, liver, spleen, and gut). The phenotype of this mouse will be A. no naïve B cells B. no naïve T cells C. naïve T cells with reduced expression of OVA-specific TCRs on cell surface D. naïve B cells with reduced expression of OVA-specific BCRs on cell surface E. naïve B cells with increased expression of OVA-specific BCRs on cell surface
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- Match the stage of B cell development with the rearrangement or expression of immunoglobulin genes. Stem cell Early pro-B cell Late pro-B cell Large pre-B cell Small pre-B cell Immature B cell ✓Choose... V-DJ rearranging germline configuration for both light and heavy chain genes D-J rearranging V-J rearranging u heavy chain plus lambda or kappa light chains on cell surface μ heavy chain made but light-chain genes in germline configuration Choose... Choose... ➡ →1. If an lg has a hydrophilic C terminus, then which of the following is true of the cell? The cell is a B cell and the immunoglobulin is bound to the membrane. A. B. C. D. E. The cell is a B cell and is producing IgA. The cell is a plasma cell and is secreting antibodies. The cell is an immature B cell and is secreting antibodies. The cell is a naive Plasma cell and is producing immunoglobulin.T-cell receptor diversity is controlled by Select one: DNA recombination during prophase of meiosis | O b. DNA recombination during prophase of meiosis II O C. DNA recombination during mitosis in T-cells O d. proteasomal degradation of host proteins proteasomal degradation of viral proteins
- 1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv1. True or False: Negative selection of transitional B cells in the spleen removes B cell clones whose BCR recognizes self antigens that weren't expressed in the bone marrow. 2. Which of the following statements about the pre-BCR is false? A. Transiently expressed with the IgM isotype in its constant region. B. Signals in an antigen-independent manner. C. Consists of a rearranged immunoglobulin light chain paired with a surrogate immunoglobulin heavy chain (VpreB). D. Consists of a rearranged immunoglobulin heavy chain paired with a surrogate light chain (VpreB + lambda5) 3. True or False: The class switch recombination of IgA antibodies is induced by TGF-beta or IL-21, and IgA antibodies can be transported across the placental interface as pentameric (5 member) oligomers. 4. A newborn infant has not started breastfeeding yet. Which isotype of maternal antibody/antibodies does the newborn have that they received from their mother while in utero? A. IgD only B. IgA only…T-cell receptor diversity is controlled by O b. O c. 1 O d. e. DNA recombination during mitosis in T-cells DNA recombination during prophase of meiosis II DNA recombination during prophase of meiosis l proteasomal degradation of viral proteins proteasomal degradation of host proteins
- 19. The following event does not occur in the germinal centers of activated B cells? A. somatic hypermutation. B. formation of memory B cells C. RNA recombination D. plasma cell formation 20. Features of T-independent immune response include? A. occurs in people that lack a functional thymus C. give rise to memory cells. 21 Thafall E. class switching B. production of IgG and IgA D. involve immunological synapse1.A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement. 2.Which of the following antibody classes or isotypes facilitate the sequential binding of the C1, C4, C2, and C3 components of the complement system? A. IgAandIgD B. IgAandIgE C. IgDandIgM D. IgE and IgG E. IgMandIgGAll of the following statements regarding immunoglobulin gene rearrangement are true except a. Non-B cells retain their chromatin containing the immunoglobulin loci in a ‘closed’ configuration. b. T-cells never transcribe immunoglobulin genes. c. There is only one promoter on the heavy-chain locus that is 5ʹ of the V segments. d. Pax-5, a transcription factor, interacts with enhancer sequences positioned 3ʹ of the heavy-chain C-region genes. e. Transcription of immunoglobulin loci precedes gene rearrangement.
- 277. Which of the following best describes the reason that the B cell receptor cannot transduce signals to the inside the cell once it binds antigen? A. The receptor requires twice the amount of antigen to be activated because it contains two sites. antigen binding b. lga is rapidly dephosphorylated c. The cytoplasmic domain of the receptor consists of 3 amino acids. d. Immunoglobulins (Ig) are inflexible molecules1. Transgenic mice are generated that are capable of expressing the poly-immunoglobulin receptor. Secretion of whic of the following antibody isotypes will be altered in these mice (a) IgA (b) IgD (c) IgE (d) IgG1) Dysfunctional repair of DNA double strand breaks often results in SCID because: (Choose all that apply) DNA must be broken as part of B cell development. B cells fail to develop and instead die. а. b. С. DNA must be broken as part of T cell development. d. |T cells fail to develop and instead die.