14. Antithrombin is a drug that is approved by the U.S. Food and Drug Administration (FDA) to treat b clotting problems in humans. It is produced by modifying the genes of goats. The drug is then produced using the milk from the genetically modified goats. Although the FDA has approved the s of this drug, some people disagree with its production. What might be one advantage of producing antithrombin this way? (a(: Identify one reason a nerson would think modifying goat genes for the production of a human drug could be a bad ided bad lsbo
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- 4) Goats have been genetically modified to produce an anticlotting protein in their milk. The protein is extracted from the milk and given to humans who have inherited a disorder that causes their bodies to produce blood clots. A benefit of the technology used to produce this protein is that it a) can be used by people to overcome the effects of a harmful mutation b) can provide people with a new kind of nutrient-rich milk c) will result in healthier goats with more nutritious milk for their offspring d) will reduce blood clots in other farm animals that are modified in this way45) A patient's mother died from an incurable neurological disease. The patient wants to test his 3-year-old daughter for the mutation. You advise him: A) B) ANS. B have her testes because she can be helped Delay it till she is an adult32. A 23-year-old man comes to the physician because of a 1-month history of weakness and muscle pain after vigorous exercise. His mother, sister, and grandmother have a similar condition; however, his father's sister and her children are unaffected. A muscle biopsy specimen shows ragged red fibers. This condition most likely results from a mutation in a gene located in which of the following labeled structures in the photomicrograph? 00 O O A) B) E) B A E D C AR
- 1. What genetic changes can occur in bacteria to make them resistant to triclosan?2. How could the ability of bacteria to convert saturated fatty acids to unsaturated fatty acids be targeted by antibiotics?3. In a patient with tuberculosis carrying 1012 M. tuberculosis cells, (a) how many bacterial cells are expected to be resistant to isoniazid given a mutation rate of 1 in 108, and (b) how many bacterial cells are expected to be resistant to a combination of three antibiotics, assuming a similar mutation rate?4. Does the ability of cerulenin to stimulate fatty acid oxidation contribute to its antifungal effects?1) Given the image below, describe what is happening at each of the 3 sections (i.e. 1, 2, and 3) . [In section 1, the gene donor is providing..., In section 2..., In section 3...]6a. Complete this flowchart to describe an example of how different versions of a gene can result in different characteristics. In the DNA, different versions of the gene for a clotting protein have a different sequence of different sequence of . in MRNA different sequence of in the clotting protein different structure and function of the clotting protein different characteristics (e.g. normal clotting vs. hemophilia)
- 23. gene amplification results in larger amounts of gene products true or false7) The protein VEGF plays an important role in stimulating the formation of new blood vessels. In some circumstances, cancer cells will produce too much VEGF. The drug PTC299 is currently being researched as a potential anti-cancer drug. It works by binding to VEGF mRNA, stopping this mRNA from being read by the ribosome. Therefore, not as much VEGF protein is produced. (National Cancer Institute. nd. NCI Drug Dictionary. Retrieved from: https://www.cancer.gov/publications/dictionaries/cancer-drug/def/vegf-inhibitor-ptc299) a) If approved, what kind of cancer treatment would it be considered (radiotherapy, gene therapy. anti-angiogenesis)? b) Briefly explain why you think PTC299 fits the kind of cancer treatment you indicated in a). Use information from the text to support your answer. c) Would PTC299 be considered a traditional or a targeted therapy?2. Sam is an immunologist who has designed a DNA vaccine for COVID-19. The vaccine has just entered a phase 3 clinical trial. To test its effectiveness, he is thinking of using ELISA to detect the presence of anti-COVID-19 antibodies in volunteers who have received the vaccine. (a) Suggest an advantage and a disadvantage of DNA vaccines. (b) Briefly explain how the DNA vaccine can stimulate the production of anti-COVID-19 antibodies in vaccinated individuals. (c) Design an indirect ELISA for Sam to screen for anti-COVID-19 antibodies in the volunteers. Describe in detail how the immunoassay should be performed.
- 45) Following a hike in the woods, you encounter an angry rattlesnake as you are approaching your car. Not knowing it was there, you stepped on its tail and it proceeded to bite you. Luckily you were close to the hospital and a fellow hiker drove you there. Once there, you were given an antivenom serum, which the doctor explained as an immunoglobulin made by sheep but injected into human snake bite victims. What type of process is this describing? A) Naturally acquired passive immunity B) Naturally acquired active immunity C) Artificially acquired passive immunity D) Artificially acquired active immunity/20. In class, we discussed diffferent types of genetic change that can cause a normal gene (proto- oncogene) to become a cancer-causing gene (oncogene), Which of the following would not be a cause? A) translocation or transposition (movement of DNA within the same genome) B) gene ampliffication (increased number of copies of a given gene) C) epigenetic change D) point mutation that changes the gene's product E) loss of telomeres during DNA replication ancer?Give 4 examples of transcription factors / non-structural proteins you have learned in this course? Identify the most commonly used technique for diagnosing COVID-19? And the clinical sample for each technique. …….…… virus can cause encephalitis, cancer, sexually transmitted disease, infect external genitalia, mucosal surfaces, gladiatorum, and/or other diseases. How can the infection with this virus be avoided? Suggest two ways of prevention or to destroy the virus.