10. (15 pts) (a) Saquinavir is an antiviral agent that acts against HIV-protease. Assess the structure in terms of Lipinski's rules and Veber's parameters (log P = 4.2; polar surface area = 167 Å). (b) Suggest five possible regions in saquinavir that might be susceptible to metabolism and identify the possible metabolite formed. N IZ || H ZI Ill Il Saquinavir I Z H H

10. (15 pts) (a) Saquinavir is an antiviral agent that acts against HIV-protease. Assess the structure in terms of Lipinski's rules and Veber's parameters (log P = 4.2; polar surface area = 167 Å). (b) Suggest five possible regions in saquinavir that might be susceptible to metabolism and identify the possible metabolite formed. N IZ || H ZI Ill Il Saquinavir I Z H H

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter22: Reactions Of Benzene And Its Derivatives

Section: Chapter Questions

Problem 22.51P

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