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Increasing Exposure To Antibody-Stimulation : A Case Control Report

Decent Essays

The report that was analysed was titled, “Increasing Exposure to Antibody-Stimulating
Proteins and Polysaccharides in Vaccines is not associated with Risk of Autism” (Frank
DeStefano, Cristofer Price and Eric Weintraub, 2013)

a. Sample size and repetition
The researchers analysed data from a case control study conducted in three managed care organizations of 256 children with autism spectrum disease and 752 children matched on birth year, sex and managed care organization (MCO). A total of 1001 children were tested.

b. Sample selection techniques and control of constant variables (e.g. Are samples randomly selected. What attempts are made to control variables).

The researchers analysed data from a case study, conducted in three …show more content…

iii. The precision of the instruments / methods used, (How much of the results is just opinion or estimate rather than detailed measurement? Could the measuring techniques be improved upon?

The researchers performed a secondary analysis of publicly available data from a case control study designed to examine associations between exposure to injections and ASD. The study was conducted in three managed care organizations. The test obtained children’s vaccination histories from computerised immunizations tracking systems and abstracted medical charts. They adapted published data on the anti-body stimulating proteins content of selected vaccines to determine the antigen loads in the various vaccines. They evaluated antigen exposures for three age ranges according to 2 measures. Cumulative exposures to antigens within the specified age range and the maximum number of covariates, including child and family characteristics, maternal exposures during pregnancy, childbirth conditions, early childhood health conditions and maternal healthcare – seeking behaviour (cholesterol or Pap smear scannings).

The study did rely on the correct information being provided by the families and subjects since much of the data was sourced through interviews and computerised tracking systems e.g. it is unknown how reliable the information relating to exposures during pregnancy and child-birth was. I would

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