Inflected forms: pl. a·gon·es ( -gnz) 1. A conflict, especially between the protagonist and antagonist in a work of literature. 2. The part of an ancient Greek drama, especially a comedy, in which two characters engage in verbal dispute. 3. A test of will; a conflict: Freud's originality stemmed from his aggression and ambition in his agon with biology (Harold Bloom). 4. A contest in ancient Greece, as in athletics or music, in which prizes were awarded.