The New Dictionary of Cultural Literacy, Third Edition. 2002.
Prozac®
This widely used antidepressant drug works by modifying the behavior of neurotransmitters in the brain. It is the first of a series of psychoactive drugs that work in this way.
The high degree of effectiveness of Prozac in treating depression has spurred debate over whether such drugs should be used for milder problems, such as shyness, or even used simply to improve an otherwise normal mood.
References to Prozac are sometimes mildly derogatory, indicating a psychological state in which true feelings have been replaced by a drug-induced tranquility.