stays the same, increases, or decreases are choices for first part Why is malonate not a substrate for succinate dehydrogenase?Malonate has two carboxylic acid groups.Malonate only has one methylene group.Malonate lacks a thioester bond that has high transfer potential.Malonate is not large enough to bind to the enzyme. Malonate is a competitive inhibitor of succinate dehydrogenase.COOCH₂COOMalonateDetermine how the concentration of each citric acid cycle intermediate will change immediately after the addition of malonate.The concentration of citrate willThe concentration of isocitrate willThe concentration of a-ketoglutarate willThe concentration of succinyl CoA willThe concentration of succinate willThe concentration of fumarate willThe concentration of malate willThe concentration of oxaloacetate will

The reaction catalyzed by succinate dehydrogenase is given below.Succinate + FAD Fumarate + FADH2In…

Why is malonate not a substrate for succinate dehydrogenase? Malonate has two carboxylic acid groups. Malonate only has one methylene group. Malonate lacks a thioester bond that has high transfer potential. Malonate is not large enough to bind to the enzyme.

Why is malonate not a substrate for succinate dehydrogenase? Malonate has two carboxylic acid groups. Malonate only has one methylene group. Malonate lacks a thioester bond that has high transfer potential. Malonate is not large enough to bind to the enzyme.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway

Section: Chapter Questions

Problem 11P: Understanding the Mechanisms of Reactions Related to Transketolase The mechanistic chemistry of the...

See similar textbooks

Related questions

Q: Which of the following statements regarding DNA is false? Features a beta glycosidic bond between…

A: DNA or deoxyribonucleic acid is a genetic material that transfers genetic information from one…

Q: Which of the following amino acids are most likely to be present on the surface of Protein A in the…

A: Proteins are big molecules. The hydrophobic effects are generally predominant weak interactions to…

Q: Glycogen can form alpha 1-->4 and beta 1--> 6 linkages alpha 1--> 4 and alpha 1--> 6 linkages alpha…

A: Classification of carbohydrates: Monosaccharide: it composed of single sugar molecule. Example:…

Q: Of the steps listed below, which problem would take you the longest to realize you had a problem in…

A: Receptor tyrosine kinases are abbreviated as RTKs.They constitute one class of transmembrane…

Q: Describe the structures of glutamine and alanine. What are the characteristics of the R-groups?…

A: There are four types of biological macromolecules: nucleic acid, proteins, lipids and…

Q: Nigerose is a disaccharide that consists of two glucose units linked by an a(1-3) bond. Use the…

A: Two-dimensional representations of the cyclic structure of monosaccharides are called Haworth…

Q: Suppose the coding (sense) strand of some DNA has this base sequence: 5-GATGTATA-3' Write the base…

A: Nucleic acids are the biomolecules that essential for the existence of life. They are the genetic…

Q: Creat a diagrammatic flow of the steps in sandwich ELISA and explain

A: The complete form of sandwich ELISA is sandwich enzyme-linked immunosorbent assay. This assay is a…

Q: isoprenoid precursors

A: Question A asks which isoprenoid precursor, IPP or DMAPP, is more susceptible to SN1 reaction. DMAPP…

Q: Which monosaccharide is known as blood sugar in the body? glucose galactose fructose

A: Monosaccharide is a simple sugar consisting only of one unit ("mono" means one). They serve as…

Q: Would you expect this molecule to spontaneously assemble into a liposome? Why or why not? CH2−O CH-O…

A: There are four classes of biological macromolecules- nucleic acid, proteins, lipids and…

Q: Which of the following would spontaneously form a liposome if suspended in aqueous solution at pH 7…

A: There are four classes of biological macromolecules - proteins, nucleic acids, lipids and…

Q: Why would glutamate utilize the oxidative deamination pathway over transamination – especially if…

A: The oxidative deamination pathway is the pathway which involves the conversion of an amino acid to a…

Q: Why does the lack of glucose 6-phosphatase activity in the brain and muscle make good physiological…

A: Carbohydrates are important source of energy and provide nutrients to your body's organs, The…

Q: Carbohydrate Chemistry Overall, what are the reactions and characteristics of sugars or…

A: There are 4 classes of biological macromolecules: proteins, nucleic acid, lipids and carbohydrates.A…

Q: Note: the reaction volumes will be 20 μL and n = 10 reactions! Assume you extract gDNA quantitated…

A: Genomic deoxyribonucleic acid (abbreviated as gDNA) represents chromosomal DNA. This DNA is in…

Q: Which of the following statements is WRONG with regard to the following molecule?

A: A cell is the basic structural and functional unit of life where all the metabolic activities are…

Q: You are working in a lab and want to assess ETC activity in response to various compounds. To do…

A: The electron transport chain is made up of four protein complexes that combine redox processes to…

Q: A. Provide a reasonable mechanism for the production of geranyl pyrophosphate from IPP and DMAPP B.…

A: The pyrophosphate ester of the terpenoid geraniol is geranyl pyrophosphate (GPP), often referred to…

Q: All of the following statements about the B-oxidation pathway are true except: The pathway is…

A: In metabolism, β-oxidation is the catabolic process by which fatty acid molecules are broken down.…

Q: How are oxytocin and vasopressin related?!. They are synthesized in the hypothalamus.II. They have 8…

A: Oxytocin is a neuropeptid. that is released by the posterior pitutary gland. This hormone has been…

Q: 4. Two common buffers in biological research are PBS and TBS. What are the compositions of these…

A: Hello! Thank you for the question. Due to time constraints, we will be able to provide the solution…

Q: Metabolizing a fatty acid via the B-oxidation pathway will generate acetyl CoA, NADH and FADH2.…

A: Fatty acids are carboxylic acids with a hydrocarbon chain ranging from 4 carbons to 36 carbons.…

Q: [AktivGrid] Draw the ketone body formed in ketogenesis from the condensation of two acetyl CoA…

A: Acetyl-CoA is a molecule that plays an important role in many biochemical reactions in protein,…

Q: Opiate drugs bind to receptors in the brain for: Group of answer choices endorphins.…

A: Opiate drugs, including substances like morphine and heroin, play a significant role in medication…

Q: Describe ketone bodies and their role in metabolism.

A: Ketone bodies are a group of three water-soluble compounds: acetoacetate, beta-hydroxybutyrate and…

Q: Calculate the membrane potential in the transport of Cl- from the intracellular environment to the…

A: Change in Gibbs free energy () for ion transport across a membrane is contributed by the…

Q: 4. What are enzymes and what are the characters of enzymes?

A: Enzymes are proteins that quicken chemical reactions to function as biological catalysts. Substrates…

Q: A mutated form of the a subunit of the heterotrimeric G protein has been identified. It is found to…

A: Heterotrimeric G proteins have 3 subunits; , and . GPCRs (G protein coupled receptors) are…

Q: Draw the product of the dehydration reaction of the B- hydroxyacyl-SACP catalyzed by…

A: Fatty acid synthesis is the process of creating fatty acids from acetyl-CoA and malonyl-CoA in the…

Q: The purpose of fermentation reactions is: a) to provide more glucose for glycolysis b) to…

A: The purpose of fermentation reactions is to keep glycolysis going under low oxygen conditions by…

Q: Out of starch, glycogen, cellulose and chitin, carbohydrate polymers with beta linkages are O…

A: The alpha and beta linkages are types of glycosidic linkages which are formed between the hemiacetal…

Q: A paste of starch was tested using Benedict’s test, the Iodine Test, and Fehling’s Test. Before…

A: There are four types of biological macromolecules- nucleic acid, proteins, lipids and…

Q: For the following reaction mechanism, which of the following statements would be false? R" R :B NO R…

A: Enzymes are proteins that catalyze biochemical reactions. Some enzymes require non non-protein…

Q: The reaction catalyzed by aconitase converts citrate to isocitrate. It is strongly inhibited when it…

A: Citrate, also known as citric acid is an organic compound. It is devoid of any colour and has a weak…

Q: Calculate the potential yield of ATP equivalents that are produced from the complete oxidation of a…

A: In order to process the fatty acid present in the cytosol is converted into fatty acyl-CoA. It is…

Q: Match each of the following aspects of triacylglycerols (TAGs) with the main structural feature…

A: There are four classes of biological macromolecules - they are nucleic acid, proteins, lipids and…

Q: Consider the graph below. Reaction rate (v) Vmax 0 Effector 3 mM Effector 1, mM Control 0 mM Ko.5…

A: Enzymes are biological catalysts that increase the rate of biochemical reactions.Most enzymes are…

Q: Which of the following contributes to the diversity of proteins that human life has? Select all that…

A: The central dogma of molecular biology is a theory that states that genetic information flows only…

Q: Uridine monophosphate (UMP) undergoes a deuterium exchange in deuterated water as shown below.…

A: As we know, water is made up of two hydrogen atoms covalently bonded to single oxygen atom. Hydrogen…

Q: . List two compounds that can be produced from pyruvate in skeletal muscle b. What are the enzymes…

A: Pyruvate is a three-carbon molecule produced from oxidation of glucose. The process of oxidation of…

Q: Liquid hexane (CH,(CH₂) CH) will react with gaseous oxygen (0.) to produce gaseous carbon dioxide…

A: Mass of hexane = 18.g Mass of oxygen gas = 32.6 gMinimum mass of hexane left over by the chemical…

Q: An inactive protease is called a: a) proteome b) protogene c) zymogen d) protein ball…

A: The objective of the question is to test the understanding of various concepts in biochemistry,…

Q: TRUE OR FALSE: The most reactive part of the ATP molecule is the triphosphate group. Creatine…

A: The objective of the question is to determine the truthfulness of several statements related to…

Q: Yo₂ 1.0 0.8 0.6 0.4 0.2 0 Weak-binding 20 Transition from weak- to strong-binding Strong-binding 40…

A: The protein hemoglobin is a molecule which is responsible for carrying almost all of the oxygen in…

Q: Why is there no peak in the region between 2300-2310 cm-1?

A: The question is asking why there is no peak in the infrared (IR) spectrum in the region between…

Q: a protein with a molar mass of 3800 g/mol is given. determine the number of nucleotides contained in…

A: The genetic information for protein synthesis is stored in the DNA. The genetic information is…

Q: Below are several structures of a triacylglyceride. Which of the structures is drawn correctly?…

A: Triglycerides are esters,Triglycerides are made up of a glycerol molecule bound to three fatty acid…

Q: Complete the sentences about unusual DNA structures. some secondary structures. Any sequence, such…

A: There are four classes of biological macromolecules: proteins, nucleic acids, lipids and…

Q: We did an experiment about carbohydrate chemistry and the prof did not elaborate on the details. She…

A: There are four types of biological macromolecules- nucleic acid, proteins, lipids and…

Question

stays the same, increases, or decreases are choices for first part

Why is malonate not a substrate for succinate dehydrogenase?
Malonate has two carboxylic acid groups.
Malonate only has one methylene group.
Malonate lacks a thioester bond that has high transfer potential.
Malonate is not large enough to bind to the enzyme.

Malonate is a competitive inhibitor of succinate dehydrogenase.
COO
CH₂
COO
Malonate
Determine how the concentration of each citric acid cycle intermediate will change immediately after the addition of malonate.
The concentration of citrate will
The concentration of isocitrate will
The concentration of a-ketoglutarate will
The concentration of succinyl CoA will
The concentration of succinate will
The concentration of fumarate will
The concentration of malate will
The concentration of oxaloacetate will

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1: Succinate dehydrogenase reaction

VIEW

Step 2: Inhibition of succinate dehydrogenase by malonate

VIEW

Step 3: Immediate change observed in citric acid cycle intermediates due to inhibition by malonate

VIEW

Solution

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 4 steps with 3 images

SEE SOLUTION Check out a sample Q&A here

Similar questions

The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.
Cytochrome oxidase and succinate-CoQ oxidoreductase are isolated from mitochondria and are incubated inthe presence of oxygen, along with cytochrome c, coenzyme Q,and succinate. What is the overall oxidation–reduction reactionthat can be expected to take place?
Some bacteria use the citric acid cycle intermediate, α-ketoglutarate, plusacetyl-CoA, as the starting point for lysine biosynthesis. The first partof this biosynthetic pathway uses the same chemical strategy found inthe citric acid cycle. Propose a four-step pathway for the conversion ofα-ketoglutarate to 2-oxoadipate. Draw the three missing intermediates, andindicate the chemistry involved in each reaction. Include any cofactors thatyou think might be required for specific steps.
Galactose derived from lactose during milk consumption can be metabolized via the glycolytc pathway. Arrange the intermediates of galactose metabolism via glycolysis in order trom the first intermediate to the last intermediato. UDP-glucose Galactose UDPgalactose Galactose 1-phonphate
Fatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved
Some metabolic enzymes undergo large-scale conformational changes to prevent undesirable sidereactions. Provide one example of an enzyme involved in glycolysis or the citric acid cycle thatundergoes a conformational change upon substrate binding. What is the undesirable side reactionthat the conformational change avoids?
Fatty acids are oxidized by acyl COA dehydrogenase. Branched fatty acids, containing a methyl group at beta carbons cannot be oxidized by this enzyme. How does the oxidation of such branched fatty acids take place? Explain with all set of reactions and enzymes involved.. give necessary detail.. avoid cpy righting
The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, answering with only one option is incorrect. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4
Compare and contrast Pyruvate Dehydrogenase with a-ketoglutarate dehydrogenaseOutline the mechanisms of both enzymes. Discuss the functions of the coenzymes. List the similarities and the differences between the 2 enzymes. Both are very large membrane bound complexes. What are the advantages of this strategy?Do a bit or research on the structure one of these enzymes. (include one recent reference) – How detailed is the enzyme structure known? What insight(s) does this structural detail give you about the enzyme mechanism.
The citric acid cycle is shown. The methyl carbon in acetyl CoA is labeled with C14C14 (shown in red). Identify which of the carbons in each intermediate will be labeled in the first round of the cycle by selecting the indicated carbon(s). Each question has multiple options, please choose more than one. Which carbon(s) in α‑ketoglutarate will contain C14? 1 2 3 4 5 Which carbon(s) in succinyl‑CoA will contain C14? 1 2 3 4 Which carbon(s) in succinate will contain C14? 1 2 3 4 Which carbon(s) in fumarate will contain C14? 1 2 3 4 Which carbon(s) in malate will contain C14? 1 2 3 4 Which carbon(s) in oxaloacetate will contain C14? 1 2 3 4
Glucose is completely metabolized to six molecules of CO 2. What specifi c reactions generate each molecule of CO 2?
In steroid synthesis, squalene is oxidizedto squalene epoxide. This reaction is somewhat unusual, in thatboth a reducing agent (NADPH) and an oxidizing agent (O2) arerequired. Why are both needed?