Which one of the following statements does NOT correctly describe the current state of the chymotrypsin-substrate complex below or the next mechanistic step that occurs? G193 NH S195 -NH R -NH R-NH HN- Ser-195 His-57 HN Asp-102 OA. This intermediate is part of a nucleophilic acyl substitution reaction. O B. In the next step His-57 protonates Ser-195. OC. In the next step His-57 activates a water molecule. O D. In the next step His-57 protonates the leaving group. OE. In the next step the N-terminal fragment of the original substrate departs.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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QUESTION 10
Which one of the following statements does NOT correctly describe the current state of the chymotrypsin-substrate complex below or
the next mechanistic step that occurs?
s,'
G193
S195 NH
NH
R
-NH
R-NH HN-
Ser-195
His-57
HN
Asp-102
OA. This intermediate is part of a nucleophilic acyl substitution reaction.
OB. In the next step His-57 protonates Ser-195.
O C. In the next step His-57 activates a water molecule.
O D. In the next step His-57 protonates the leaving group.
OE. In the next step the N-terminal fragment of the original substrate departs.
Transcribed Image Text:QUESTION 10 Which one of the following statements does NOT correctly describe the current state of the chymotrypsin-substrate complex below or the next mechanistic step that occurs? s,' G193 S195 NH NH R -NH R-NH HN- Ser-195 His-57 HN Asp-102 OA. This intermediate is part of a nucleophilic acyl substitution reaction. OB. In the next step His-57 protonates Ser-195. O C. In the next step His-57 activates a water molecule. O D. In the next step His-57 protonates the leaving group. OE. In the next step the N-terminal fragment of the original substrate departs.
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