In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATPand glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATPto glucose.Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation?ATP hydrolysis is thermodynamically unfavorable compared to group transfer.Glucokinase increases the transition state energy, favoring glucose phosphorylation.The process takes advantage of the high phosphoryl group transfer potential of ATP.Reaction intermediates do not need to be present in excess.Incorrect

Glucokinase is the enzyme that catalyzes the phosphorylation of glucose in hepatocytes. Here the…

Answered: In hepatocytes, the enzyme glucokinase…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter2: Cell Physiology

Section: Chapter Questions

Problem 3SQE

See similar textbooks

Similar questions

In hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? Glucokinase increases the transition state energy, favoring glucose phosphorylation. Reaction intermediates do not need to be present in excess. The process takes advantage of the high phosphoryl group transfer potential of ATP. ATP hydrolysis is thermodynamically unfavorable compared to group transfer.
During glycolysis (under anaerobic conditions), for each glucose molecule broken down, how many ATP molecules are used and how many are made in total? A diagram summarizing the different reactions of glycolysis is given below. ATP ADP ATP ADP Glucose Glucose-6-phosphate Fructose-6-phosphate Fructose-1,6-bisphosphate Dihydroxyacetone phosphate 2 (Glyceraldehyde-3-phosphate) Glyceraldehyde- 3-phosphate 2 (1,3-Bisphosphoglycerate) 2 (3-Phosphoglycerate) 2 (2-Phosphoglycerate) 2 H₂O 2 (Phosphoenolpyruvate) 2 (Pyruvate) 2 NAD+ + 2Pi 2 NADH + 2H 2 ADP 2 ATP -2 ADP 2 ATP 2 ATP molecules are used and 2 ATP molecules are made 2 ATP molecules are used and 4 ATP molecules are made O 6 ATP molecules are used and no ATP molecules are made O 4 ATP molecules are used and 2 ATP molecules are made O No ATP molecules are used and 6 ATP molecules are made
Select the correct statement regarding electrochemical gradients. Thermodynamically, electrochemical gradients will maintain their relative concentrations across both sides of the membrane. The cytoplasmic side of the cell membrane has a net positive charge relative to the extracellular side. Ions can freely pass through the cell membrane. Electrochemical gradients are sources of potential energy due to the differences in concentrationsand charge across both sides of the cell membrane. Select the correct statement(s) about transfer RNAs. Codon recognition occurs through specific base-pairing by the anticodon arm. Amino acids are linked to the T-loop. They are transcribed by RNA Polymerase III. There is strict matching requirements at the third position, else the tRNA cannot interact with the codon.
Complete catabolism of one glucose molecule yields 38 ATP molecules. How many moles of ATP are produced by the complete catabolism of 10 moles of glucose?
Several general characteristics of metabolic reactions or reaction pathways are listed. Classify them into the appropriate metabolic category. utilize ATP Anabolism convert NAD+ to NADH convert small compounds to larger compounds Answer Bank convert NADPH to NADP+ generally exergonic (spontaneous) Catabolism convert large compounds to smaller compounds
Consider ten glucose molecules that enter a cell. How many ATP can be generated by the complete catabolism of these into CO2 and H2O? If all ten are first incorporated into glycogen, liberated from glycogen, and then fully catabolized into CO2 and H2O, does the ATP tally increase, decrease or stay the same? Consider that 1 UTP = 1 ATP. Explain. Describe the processes which produce ATP and provide a balanced equation of glucose, CO2, H2O and O2
You are studying energy production and metabolic activities of prostate cancer cells in the lab. You compare energy metabolism in these cancer cells with normal cells. Which of the following would you observe? Select all that apply Oxidative phosphorylation is reduced in cancer cells compared to normal cells Glycolysis is reduced in cancer cells compared to normal cells Oxidative phosphorylation is enhanced in cancer cells compared to normal cells Glycolysis is enhanced in cancer cells compared to normal cells
The synthesis of ATP by oxidative phosphorylation, using the energy released by movement of protons across the membrane down their electrochemical gradient, is an example of which of the following processes?
iodoacetate is an irreversible inhibitor of glyceraldehyde-3-phosphate dehydrogenase. which of the following is the expected outcome of the exposure of a cell to iodoacetate - Cellular resiration will stop if the cell solely depends on glucose as fuel - The rate of cellular respiration will increase - The reoxidation of coenzymes will noy be affected , but the efficiency of oxidative phosphorylation will be diminished - There will be no effect on cellular respiration as long as the cell has a large glucose reserve -The cell sill not be able to reoxidize the reduced coenzymes
Which of the following is the correct summary of phase II of glycolysis for each molecule of glucose? Glucose + ATP ⟶ Glyceraldehy-3-phosphate + ADP Glucose + 2 ATP ⟶ 2(Glyceraldehy-3-phosphate) + 2 ADP Glyceraldehyde-3-phosphate + NAD+ + ADP + Pi ⟶ 3-phosphoglycerate + NADH + H+ + ATP 2(3-phosphoglycerate) + 2ADP ⟶ 2 pyruvate + 2ATP 2(Glyceraldehyde-3-phosphate) + 2NAD+ + 2ADP + 2Pi ⟶ 2(3-phosphoglycerate) + 2NADH + 2H+ + 2ATP
Provide a table for each question, listing all of the particular individual reactions that will generate ATP either through substrate level phosphorylation (SLP) or oxidative phosphorylation (OP). If the question calls for a shuttle system, please use both and calculate the net ATP for each. Question: glucose 6-phosphate to 2 succinyl CoA Sample table: 1,3 bisphosphoglycerate to 3-phosphoglycerate Specific reaction Number of ATP (- or +) 1, 3 bisphosphoglycerate to 3- 3 ATPS from OP via NADH + H in MA shuttle or phosphoglycerate 2 ATPS from OP via FADH2 in GP shuttle Net ATP 3 via MA or 2 via OP
We have discussed the aerobic metabolism of glucose extensively in this class. To capture and use the energy in glucose to make ATP, we must utilize 4 different sequential pathways/steps. Starting with one glucose molecule and eventually ending with CO2, H20 and ATP, list the 4 pathways/steps in order and tell me what molecules enter each pathway, and what the final products of each pathway are.

SEE MORE QUESTIONS

Recommended textbooks for you

Human Physiology: From Cells to Systems (MindTap …

Biology

ISBN:

9781285866932

Author:

Lauralee Sherwood

Publisher:

Cengage Learning