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The following dose-response curve depicts the physiological response to a drug or combination of drugs as a function of agonist concentration. First, post an explanation of the different curves noted in regards to the type of each drug administered. There may be more than one answer.
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- Briefly explain this statement -"Therapeutic drug monitoring of Warfarin" Please answer at your own words.1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…Please Write the Drug Discovery Process of Diltiazem? Please write at your own words.
- What are the different methods for developing modified release drug delivery system ? Discuss about the matrix and encapsulation drug release systems. Please explain at your own words.INTERPRETATION OF RESULIS NEGATIVE: Two lines appear. One colored line should be in the control region (C), and another apparent colored or faded color line adjacent should be in the test region (T). This negative result indicates that the drug concentration is below the detectable level. POSITIVE: One colored line appears in the control region (C). No line appears in the test region (T). This positive result indicates that the drug concentration is above the detectable level. INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test using a new test panel. If the problem persists, discontinue using the lot immediately and contact your local distrībutor. READING OF RESULTS INTERPRETATION SONTROL TEST SAMPLEWhat is Anti-D Drug?
- CHOICES: Isoniazid Rifampicin Ethambutol None of the Choices Causes more adverse effects to slow acetylators Causes optic neuritis Causes orange secretions Inhibits transcription process in mycobacteria Binds to bacterial DNA gyrase & topoisomeraseWhat properties of drug are relevant for developing modified release drug delivery formulation. Please briefly explain this at your own words.Which letter represents the target site of furosemide (Lasix)? E- -B
- Biotransformation is an important concept in pharmacology, which amongst others, enables the effective administration of prodrugs. Provide a detailed description of factors influencing the biotransformation of drugs.What is the mechanism of action of the drug LIDOCAINE? pls. dont plagiarizeThe mechanism of acquired drug resistance that would prohibit the drug molecule from entering a target cell would be considered: Use of alternate metabolic pathway Drug inactivation Activation of drug pumps Decreased permeability Change in drug binding site