+ E Consider a situation where valine was used by the liver for gluconeogenesis. Valine is metabolized via the ollowing pathway. NH₂ HO NH CoA valine CO₂ CoA CO₂ COO COO NAD NADH COA COA NAD NADH H" H FAD FADH2 r H₂O ATP CO₂ COA COO COO NADH NAD+ H- HO GTP GDP HO COA P₁ ADP+ P₁ COA COO COA COO succinyl CoA How many molecules of valine would be required for one molecule of glucose? Using the appropriate amount of valine determined above, how many NADH, FADH2, and ATP would be produced or consumed by the conversion of valine into glucose? If all excess NADH and FADH2 were converted to ATP by oxidative phosphorylation, what is the maximum net ATP production in the human mitochondria (10 c subunits)? Don't forget to add/subtract the ATP determined in the above question.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter27: Metabolic Integration And Organ Specialization
Section: Chapter Questions
Problem 17P
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+
E
Consider a situation where valine was used by the liver for gluconeogenesis. Valine is metabolized via the
ollowing pathway.
NH₂
HO NH
CoA
valine
CO₂
CoA CO₂
COO
COO
NAD NADH
COA
COA
NAD NADH
H"
H
FAD FADH2
r
H₂O
ATP
CO₂ COA
COO
COO
NADH NAD+
H-
HO
GTP GDP HO
COA
P₁
ADP+ P₁
COA
COO
COA
COO
succinyl CoA
How many molecules of valine would be required for one molecule of glucose?
Using the appropriate amount of valine determined above, how many NADH, FADH2, and ATP would be produced or
consumed by the conversion of valine into glucose?
If all excess NADH and FADH2 were converted to ATP by oxidative phosphorylation, what is the maximum net ATP
production in the human mitochondria (10 c subunits)? Don't forget to add/subtract the ATP determined in the above
question.
Transcribed Image Text:+ E Consider a situation where valine was used by the liver for gluconeogenesis. Valine is metabolized via the ollowing pathway. NH₂ HO NH CoA valine CO₂ CoA CO₂ COO COO NAD NADH COA COA NAD NADH H" H FAD FADH2 r H₂O ATP CO₂ COA COO COO NADH NAD+ H- HO GTP GDP HO COA P₁ ADP+ P₁ COA COO COA COO succinyl CoA How many molecules of valine would be required for one molecule of glucose? Using the appropriate amount of valine determined above, how many NADH, FADH2, and ATP would be produced or consumed by the conversion of valine into glucose? If all excess NADH and FADH2 were converted to ATP by oxidative phosphorylation, what is the maximum net ATP production in the human mitochondria (10 c subunits)? Don't forget to add/subtract the ATP determined in the above question.
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