4- Salicylamides are inhibitors for an enzyme called scytalone dehydratase. SAR shows thatthere are three important hydrogen bonding interactions. Explain whether you thinkquinazolines could act as a bioisostere for salicylamides.HBAOHO 00NNHRQuinazolinesSalicylamidesPhHBA5- Structure IX (X = NH) is an inhibitor of a metalloenzyme called thermolysin and formsinteractions as shown. Explain why the analogue (X = O) has reduced binding affinity by afactor of 1000 and why the analogue (X = SH) has roughly the same binding affinity.Structure IXHHBDAla-113R

Bioisosteres are molecules or functional groups that can be substituted for one another in drug…

Answered: 4- Salicylamides are inhibitors for an…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter24: Lipid Biosynthesis

Section: Chapter Questions

Problem 20P

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The following structure is sorbose Answer the following questions and briefly explain Draw β-D-sorbufuranose Draw β-D-sorbufuranosyl(2->1) β-D-glucopyranoside. Is this reducing sugar? What would be the probable function of this disaccharide, structural or storage?
Consider the Haworth projections of f-L-galactose and B-L-glucose shown here. ОН CH OH ОН ОН B-L-galactose enantiomers anomers OH diastereomers epimers ОН CH₂OH OH Which terms describe the relationship between these two sugars? ОН OH B-L-glucose
His388 Glu357 His388 Glu357 Ring opening Proton HO HO abstraction HO но- G6P He NH- NH His388 His388 His388 Glu357 Glu357 Glu357 HO но HO но- но OH cis-enediol F6P Ring closure intermediate OH Describe the mechanism shown above for phosphoglucose isomerase. Describe the chemistry of each step • How the enzyme appears or might facilitate the chemistry How the enzyme increases the reaction rate.
During the process of synthesizing palmitate (C16), an acyl ACP __________. For the sake of this question, don’t treat acetyl ACP or malonyl ACP as an acyl ACP; assume the acyl ACP is a product at least 4 carbons long. Choose ALL that apply. (A) can be condensed with malonyl ACP to produce a Cn+2 b-ketoacyl ACP (B) is formed from the reduction of a trans D2-enoyl ACP(C) is a product of acetyl transacylase(D) is reduced by NADPH (E) is a substrate for b-ketoacyl synthase(F) can be condensed with acetyl ACP to produce a Cn+2 b-ketoacyl ACP
The enzyme lysozyme hydrolyzes glycosidic bonds in peptidoglycan, an oligosaccharide found in bacterial cell walls. The active site of lysozyme contains two amino acid residues essential for catalysis: E35 and D52. Which of the following statements about lysozyme is true? More than one may apply The graph shows the pH-activity profile of lysozyme. 100 50 4. 6. 8. 10 pH Residue E35 exhibits general base catalysis O The pKa of E35 is approximately 4.3 O The pKa of D52 is approximately 4.5 O The optimal activity of lysozyme is approximately 5.2 Residue E35 exhibits covalent catalysis The pka of E35 is approximately 6.1 The pka of D52 is approximately 3.7 Activity (% of maximal)
(EPR) which of Lactobacillus casei fermentation of milk was found to have potent blood pressure lowering properties. Draw the structure of the tripeptide The tripeptide Glu-Pro-Arg is a product and give its systematic name. Then show its titration profile and determine its isoelectric pH.
What sugar units make up the structure shown? ÇH,OSO;- но Po- H H. ÇOO- NHCCH, H OH H H OH O D-Glucuronate and N-Acetyl-D-galactosamine-6-sulfate O D-Glucuronate and N-Sulfo-D-glucosamine-6-sulfate O D-Iduronate and N-Acetyl-D-galactosamine-6-sulfate O D-Glucuronate and N-Acetyl-D-glucosamine-6-sulfate
Vitamin C is ascorbic acid. If you examine the structure of asorbic acid given in the background secton (equation 2) there is no -COOH group present. In the structure shown, the ascorbic acid is as a lactone or cyclic ester. Write the equation for the hydrolysis (cleaveg by addition of water) of the lactone to the carboxylic acid.
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Xanthine oxidase treated with allopurinol results in the formation of a new compound that is an extremely potent inhibitor of the enzyme. Propose a structure for this compound.
At pH 7, tryptophan crosses a lipid bilayer at about onethousandththe rate of indole, a closely related compound: Suggest an explanation for this observation.
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