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2. a) Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DE' and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 Coenzyme Q → Cytochrome c₁ → Cytochrome a3 → 0₂ Table 11.1 STANDARD REDUCTION POTENTIALS (E°) FOR SELECTED ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM Electron carriers NAD +H + 2e → NADH Complex I (NADH-ubiquinone oxidoreductase) Fe-S (N-1b) Fe-S (N-3,4) Fe-S (N-5,6) Complex II (succinate dehydrogenase) FAD+ 2H +2e → FADH₂ (enzyme bound) Fe-S (S-1) Cytochrome b560 Coenzyme Q + 2 H + 2e Complex IIll (ubiquinone-cytochrome c oxidoreductase) Cytochrome by Cytochrome b Fe-S Cytochrome c₁ Cytochrome c (Cyt c) Complex IV (cytochrome coxidase) Cytochrome a CUA Cytochrome az O₂ +2H + 2e →H₂O E" (V) -0.32 -0.25 -0.24 -0.27 -0.04 -0.03 -0.08 +0.04 +0.03 -0.03 +0.28 +0.21 +0.23 +0.21 +0.24 +0.38 +0.82 Direction of flow e transferred from to NADH (Fe-S)N-5,6 (Fe-S)N-5,6 Coenzyme Q Coenzyme Q → Cytochrome c₁ Cytochrome c₁ → Cytochrome a3 Cytochrome a3→ O₂ AE⁰¹ -nFAE⁰¹= AG⁰¹

2. a) Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DE' and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 Coenzyme Q → Cytochrome c₁ → Cytochrome a3 → 0₂ Table 11.1 STANDARD REDUCTION POTENTIALS (E°) FOR SELECTED ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM Electron carriers NAD +H + 2e → NADH Complex I (NADH-ubiquinone oxidoreductase) Fe-S (N-1b) Fe-S (N-3,4) Fe-S (N-5,6) Complex II (succinate dehydrogenase) FAD+ 2H +2e → FADH₂ (enzyme bound) Fe-S (S-1) Cytochrome b560 Coenzyme Q + 2 H + 2e Complex IIll (ubiquinone-cytochrome c oxidoreductase) Cytochrome by Cytochrome b Fe-S Cytochrome c₁ Cytochrome c (Cyt c) Complex IV (cytochrome coxidase) Cytochrome a CUA Cytochrome az O₂ +2H + 2e →H₂O E" (V) -0.32 -0.25 -0.24 -0.27 -0.04 -0.03 -0.08 +0.04 +0.03 -0.03 +0.28 +0.21 +0.23 +0.21 +0.24 +0.38 +0.82 Direction of flow e transferred from to NADH (Fe-S)N-5,6 (Fe-S)N-5,6 Coenzyme Q Coenzyme Q → Cytochrome c₁ Cytochrome c₁ → Cytochrome a3 Cytochrome a3→ O₂ AE⁰¹ -nFAE⁰¹= AG⁰¹

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter20: Electron Transport And Oxidative Phosphorylation
Section: Chapter Questions
Problem 11P
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2. a) Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DE' and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 Coenzyme Q → Cytochrome c₁ → Cytochrome a3 ⇒ 0₂ Table 11.1 STANDARD REDUCTION POTENTIALS (E°') FOR SELECTED ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM Electron carriers NAD+ + H+ + 2e → NADH Complex I (NADH-ubiquinone oxidoreductase) Fe-S (N-1b) Fe-S (N-3,4) Fe-S (N-5,6) Complex II (succinate dehydrogenase) FAD + 2H+ + 2e → FADH₂ (enzyme bound) Fe-S (S-1) Cytochrome b560 Coenzyme Q + 2H+ + 2 e Complex III (ubiquinone-cytochrome c oxidoreductase) Cytochrome b Cytochrome b Fe-S Cytochrome c₁ Cytochrome c (Cyt c) Complex IV (cytochrome c oxidase) Cytochrome a Cu Cytochrome az O₂ + 2H+ + 2e → H₂O E° (V) -0.32 -0.25 -0.24 -0.27 -0.04 -0.03 -0.08 +0.04 +0.03 -0.03 +0.28 +0.21 +0.23 +0.21 +0.24 +0.38 +0.82 Direction of e flow e transferred from to NADH → (Fe-S)N-5,6 (Fe-S)N-5,6 → Coenzyme Q Coenzyme Q → Cytochrome c₁ Cytochrome c₁ → Cytochrome a3 Cytochrome a3⇒ 0₂ AE⁰¹ -nFAE⁰¹= AG⁰¹
Transcribed Image Text:2. a) Energetics of the electron transport. In the oxidative phase of oxidative phosphorylation, electrons are passed from NADH and ultimately to molecular oxygen through an electron transport chain comprised of multiple redox centers. Assume that an electron is passed through the chain along the route shown below. Clearly, there are steps missing, but we will skip those to emphasize the energetics of the electron transport. Calculate DE' and DGº' for each electron transfer step and record the values in the table. The reduction potentials for each of the redox centers are given in table 11.1. (F=96.4 kJ/V mol) Route: NADH → (Fe-S)N-5,6 Coenzyme Q → Cytochrome c₁ → Cytochrome a3 ⇒ 0₂ Table 11.1 STANDARD REDUCTION POTENTIALS (E°') FOR SELECTED ELECTRON CARRIERS IN THE ELECTRON TRANSPORT SYSTEM Electron carriers NAD+ + H+ + 2e → NADH Complex I (NADH-ubiquinone oxidoreductase) Fe-S (N-1b) Fe-S (N-3,4) Fe-S (N-5,6) Complex II (succinate dehydrogenase) FAD + 2H+ + 2e → FADH₂ (enzyme bound) Fe-S (S-1) Cytochrome b560 Coenzyme Q + 2H+ + 2 e Complex III (ubiquinone-cytochrome c oxidoreductase) Cytochrome b Cytochrome b Fe-S Cytochrome c₁ Cytochrome c (Cyt c) Complex IV (cytochrome c oxidase) Cytochrome a Cu Cytochrome az O₂ + 2H+ + 2e → H₂O E° (V) -0.32 -0.25 -0.24 -0.27 -0.04 -0.03 -0.08 +0.04 +0.03 -0.03 +0.28 +0.21 +0.23 +0.21 +0.24 +0.38 +0.82 Direction of e flow e transferred from to NADH → (Fe-S)N-5,6 (Fe-S)N-5,6 → Coenzyme Q Coenzyme Q → Cytochrome c₁ Cytochrome c₁ → Cytochrome a3 Cytochrome a3⇒ 0₂ AE⁰¹ -nFAE⁰¹= AG⁰¹
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